At the University of Illinois, we seek to train pulmonary and critical care fellows who have completed two years of clinical training and have the aptitude and commitment for two or three additional years of investigative training. We propose to integrates a minimal amount of relevant classroom work with a goal directed mentored research experience that is focused on a scientific body of knowledge related to the role of inflammation and innate immunity in a wide spectrum of lung diseases. We believe that this scientific platform pertains most broadly to a wide variety of lung diseases that share a prominent inflammatory feature and include the very prevalent diseases of asthma, COPD and other tobacco induced lung diseases, interstitial lung disease, and the acute respiratory distress syndrome. By design, we propose a two-track program that blends training in """"""""clinical trials, epidemiology, and outcomes research"""""""" with """"""""translational approaches in cellular and animal models of inflammation"""""""". Candidates accepted to the clinical science track will take four courses in relevant epidemiology and biostatistics and candidates chosen for the basic science track will complete four courses in research methods and integrated biology and physiology. Mentors are selected based on their area of expertise and interests, set of complementary research skills, achievement in extramural funding, and proven record of strong mentorship. All trainees will develop an individualized research program, learn to write grant proposals, and receive career counseling and assistance in academic job placement. The progress of the trainees will be closely monitored by a research advisory committee, internal executive committee, external advisory board, and the principal investigator. The program will be judged successful based on the academic performance of the trainees. A unique aspect of our program is that the clinical and basic tracks will be closely integrated so that individuals in both tracks will develop two separate skill sets that will synergize as a more powerful teamwork approach to the investigation of lung disease. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from underrepresented minorities.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Colombini-Hatch, Sandra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Rani, Asha; Ranjan, Ravi; McGee, Halvor S et al. (2017) Urinary microbiome of kidney transplant patients reveals dysbiosis with potential for antibiotic resistance. Transl Res 181:59-70
Shamaei, Masoud; Mirsaeidi, Mehdi; Baghaei, Parvaneh et al. (2017) Recurrent Drug-Induced Hepatitis in Tuberculosis-Comparison of Two Drug Regimens. Am J Ther 24:e144-e149
Ayee, Manuela A A; LeMaster, Elizabeth; Shentu, Tzu Pin et al. (2017) Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. Biophys J 112:325-338
Qian, Feng; Deng, Jing; Wang, Gang et al. (2016) Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases. Curr Protein Pept Sci 17:332-42
Fraidenburg, Dustin R; Machado, Roberto F (2016) Pulmonary hypertension associated with thalassemia syndromes. Ann N Y Acad Sci 1368:127-39
Prieto-Centurion, Valentin; Bracken, Nina; Norwick, Lourdes et al. (2016) Can Commercially Available Pedometers Be Used For Physical Activity Monitoring In Patients With COPD Following Exacerbations? Chronic Obstr Pulm Dis 3:636-642
Mirsaeidi, Mehdi; Banoei, Mohammad Mehdi; Nienow, Caleb K et al. (2016) Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 33:29-38
Rani, Asha; Ranjan, Ravi; McGee, Halvor S et al. (2016) A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms. Sci Rep 6:33327
Omar, Hesham R; Mirsaeidi, Mehdi; Shumac, Jacob et al. (2016) Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. J Crit Care 32:48-51
Mirsaeidi, Mehdi; Machado, Roberto F; Schraufnagel, Dean et al. (2015) Response. Chest 147:e65-e66

Showing the most recent 10 out of 62 publications