This proposal describes our research training program in the Division of Pulmonary and Critical Care Medicine, Oregon Health &Science University. In this program, we offer state of the art, multidisciplinary research training in a wide range of disciplines including cell and molecular biology, whole organ pathophysiology, and both human based research and epidemiological research. Six post-doctoral fellows (primarily MD pulmonary fellows) and two graduate students will be offered funding for two years of research training each. Research will be supplemented by trainee participation in program wide research seminars and journal clubs. It is our belief that such program wide meetings and interactions are vital to providing young scientists with a broad perspective on research outside their own projects, avoiding early overspecialization and an inappropriately narrow research focus. Course work is also offered, and includes a mandatory course in Responsible Conduct of Research, as well as a wide range of courses appropriate to trainees embarking on a research career. These include statisics, experimental design, grant writing, manuscript writing, public speaking, and epidemiological methods, and are offered both in our graduate programs and in our Human Investigations Program. Research mentorship is provided by a faculty of seasoned scientists with extensive experience in training young scientists. About half the faculty conducts research primarily or principally involving the lung. The remainder have specific areas of expertise in cell and molecular biology that have either been applied to the study of lung disease or are easily applicable to it. Interactions and synergy among the laboratories in this program add to the rich and broad training environment. A well established system for regularly tracking the progress of trainees ensures their continued development, and broadens the sources of guidance and advice in this crucial stage of their careers. This approach will produce clinical and basic researchers prepared for the challenges of academic medicine and biomedical research, and will help fill the need in the next generation of scientists. These scientists will be prepared to address the public health issues raised by the increasing burden of asthma, chronic bronchitis, emphysema, acute respiratory distress syndrome, and other lung diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Colombini-Hatch, Sandra
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Oregon Health and Science University
Internal Medicine/Medicine
Schools of Medicine
United States
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Scott, Gregory D; Blum, Emily D; Fryer, Allison D et al. (2014) Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways. Am J Respir Cell Mol Biol 51:43-55
Conti, Brian J; Elferich, Johannes; Yang, Zhongying et al. (2014) Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nat Struct Mol Biol 21:228-35
Sullivan, Donald R; Ganzini, Linda; Lopez-Chavez, Ariel et al. (2014) Association of patient characteristics with chemotherapy receipt among depressed and non-depressed patients with non-small cell lung cancer. Psychooncology 23:1318-22
Sullivan, D R; Ganzini, L; Duckart, J P et al. (2014) Treatment receipt and outcomes among lung cancer patients with depression. Clin Oncol (R Coll Radiol) 26:25-31
Drake, Matthew G; Evans, Scott E; Dickey, Burton F et al. (2013) Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs. Am J Respir Cell Mol Biol 48:790-6
Buels, K S; Jacoby, D B; Fryer, A D (2012) Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. Br J Pharmacol 165:1501-14
Kaufman, Elad H; Fryer, Allison D; Jacoby, David B (2011) Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs. J Allergy Clin Immunol 127:462-9
Devaraneni, Prasanna K; Conti, Brian; Matsumura, Yoshihiro et al. (2011) Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell 146:134-47
Vyleta, Nicholas P; Smith, Stephen M (2008) Fast inhibition of glutamate-activated currents by caffeine. PLoS One 3:e3155