This proposal describes our research training program in the Division of Pulmonary and Critical Care Medicine. In this program, we offer a multidisciplinary approach to Pulmonary research and medicine that integrates state of the art basic science, clinical trials and patient outcomes. Four post-doctoral fellows (two MD Pulmonary &Critical Care Medicine Fellows, two PhDs) and two graduate students will be offered two years of research funding. In addition, we will also be offering short term summer research experiences for diversity candidates. Research will be supplemented by trainee participation in program wide research seminars, journal clubs, and didactic coursework. It is our belief that such program wide meetings and interactions are vital to providing young scientists with a broad perspective on research outside their own projects, avoiding early over-specialization and an inappropriately narrow research focus. Course work includes a program specific course on pulmonary disease and research. It also includes a mandatory course in Responsible Conduct in Research and biostatistics. We will also offer a wide range of courses appropriate to trainees embarking on a research career. These include experimental design, grant writing, manuscript writing, human investigations, epidemiological methods and career development. These are offered in our graduate programs, our CTSA based Human Investigators Program and other university departments. Research mentorship is provided by a faculty of seasoned scientists with extensive experience in training young scientists. This program is also structured to develop faculty mentors by pairing junior mentors with more senior mentors. About half the faculty conducts research primarily involving the lung. The remainder have specific areas of expertise in cell and molecular biology that are frequently applied to the study of lung diseases. Interactions and synergy among the laboratories in this program add to the rich and broad training environment. Our trainees have been very successful given the relative youth of our training program including achieving independent research funding, faculty or industry positions in biomedical research and postdoctoral positions at other prestigious institutions.
Lung diseases such as asthma, chronic bronchitis, cystic fibrosis, tuberculosis, emphysema, acute respiratory distress syndrome, lung cancer cause substantial morbidity and mortality. This program will produce clinical and basic science investigators with broad experience in Pulmonary investigation. The training program will prepare these researchers for the challenges of academic medicine and biomedical research and will help fill the need in the next generation of scientists.
|Meermeier, Erin W; Laugel, Bruno F; Sewell, Andrew K et al. (2016) Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens. Nat Commun 7:12506|
|Youssef, Jameel; Novosad, Shannon A; Winthrop, Kevin L (2016) Infection Risk and Safety of Corticosteroid Use. Rheum Dis Clin North Am 42:157-76, ix-x|
|Laugel, Bruno; Lloyd, Angharad; Meermeier, Erin W et al. (2016) Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells. J Immunol 197:971-82|
|Novosad, Shannon A; Beekmann, Susan E; Polgreen, Philip M et al. (2016) Treatment of Mycobacterium abscessus Infection. Emerg Infect Dis 22:511-4|
|Winthrop, K L; Novosad, S A; Baddley, J W et al. (2015) Opportunistic infections and biologic therapies in immune-mediated inflammatory diseases: consensus recommendations for infection reporting during clinical trials and postmarketing surveillance. Ann Rheum Dis 74:2107-16|
|Conti, Brian J; Devaraneni, Prasanna K; Yang, Zhongying et al. (2015) Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Mol Cell 58:269-83|
|Novosad, Shannon; Henkle, Emily; Winthrop, Kevin L (2015) The Challenge of Pulmonary Nontuberculous Mycobacterial Infection. Curr Pulmonol Rep 4:152-161|
|Patterson, Melissa A; Bandyopadhyay, Anannya; Devaraneni, Prasanna K et al. (2015) The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding. J Biol Chem 290:28944-52|
|Scott, Gregory D; Blum, Emily D; Fryer, Allison D et al. (2014) Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways. Am J Respir Cell Mol Biol 51:43-55|
|Conti, Brian J; Elferich, Johannes; Yang, Zhongying et al. (2014) Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nat Struct Mol Biol 21:228-35|
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