This is a revised, new application for a training program in Hypertension research to support 3 predoctoral and 3 postdoctoral trainees. The overall goal is to produce top quality independent investigators with a strong translational approach who can develop and sustain outstanding Hypertension research programs. The training faculty consists of 35 mentors from 14 Departments (Aging, Anesthesiology, Applied Physiology &Kinesiology, Biomedical Engineering, Clinical Psychology, Medicinal Chemistry, Medicine, Pathology &Immunology, Pediatrics, Pharmacodynamics, Pharmacology &Therapeutics, Pharmacy Practice, Physiology and Functional Genomics, Physiological Sciences (Veterinary), Surgery). In addition to 4 of the 6 colleges that form the Health Science Center (Medicine, Pharmacy, Veterinary Medicine and Health-Related Professions), there is representation from the Colleges of Health and Human Performance and Engineering. The faculty consists of clinicians and basic scientists with a wide range of interests and expertise, focused on vascular endothelium and neural control of blood pressure. All the faculty are members of the Hypertension Center and participate in the seminar series and many have active collaborations with each other. The majority of the predoctoral trainees will be recruited and initially trained through the College of Medicine's Interdisciplinary Program in Biomedical Sciences (IDP). The pool of trainee grant eligible candidates from the entire US has averaged 170/year during the past 3 years with ~ 50/year entering the training program. These trainees enter with an average combined verbal plus quantitative GRE scores of -1200-1250, and undergraduate GPAs of ~3.5. The IDP provides comprehensive lecture and laboratory courses as well as laboratory rotations and advanced course work in specialized disciplines. All students receive training in bioethics, statistics and communication skills. Subsequent training focuses on independent research in the laboratory of choice. The predoctoral training takes ~ 5 years with the first year provided by the respective college, an average of 3-4 years support anticipated from the training grant and additional funds supplied by the mentors research grants. Postdoctoral trainees are recruited nationally directly into the laboratory of choice. A large pool of qualified MD fellows is available, mainly through Cardiology and Nephrology Training Programs (Medicine). Training focuses almost exclusively on laboratory research supplemented with seminars and journal clubs and other methods of development of communication skills. Postdoctoral training lasts 3-4 years with 2-3 years support anticipated from the training grant and additional funds supplied by the mentors grants.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL083810-05
Application #
8022948
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Roltsch, Mark
Project Start
2007-04-01
Project End
2013-07-23
Budget Start
2011-04-01
Budget End
2013-07-23
Support Year
5
Fiscal Year
2011
Total Cost
$201,503
Indirect Cost
Name
University of Florida
Department
Physiology
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Lee, Choong H; Bengtsson, Niclas; Chrzanowski, Stephen M et al. (2017) Magnetic Resonance Microscopy (MRM) of Single Mammalian Myofibers and Myonuclei. Sci Rep 7:39496
Welch, Amanda K; Jeanette Lynch, I; Gumz, Michelle L et al. (2016) Aldosterone alters the chromatin structure of the murine endothelin-1 gene. Life Sci 159:121-126
de Kloet, Annette D; Wang, Lei; Ludin, Jacob A et al. (2016) Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system. Brain Struct Funct 221:891-912
Chrzanowski, Stephen M; Batra, Abhinandan; Lee-McMullen, Brittany et al. (2016) Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle. Am J Pathol 186:2692-700
Strehler, Kevin Y E; Matheny, Michael; Kirichenko, Nataliya et al. (2016) Onset of leptin resistance shows temporal differences related to dose or pulsed treatment. Eur J Pharmacol 779:177-85
Massengill, Michael T; Ashraf, Hassan M; Chowdhury, Rajib R et al. (2016) Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase. Cardiovasc Res 111:34-43
Gong, Yan; McDonough, Caitrin W; Beitelshees, Amber L et al. (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens 33:2278-85
Bennion, Douglas M; Haltigan, Emily; Regenhardt, Robert W et al. (2015) Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke. Curr Hypertens Rep 17:3
Leclerc, Jenna L; Blackburn, Spiros; Neal, Dan et al. (2015) Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage. Proc Natl Acad Sci U S A 112:1155-60
Wegman, Martin P; Guo, Michael H; Bennion, Douglas M et al. (2015) Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. Rejuvenation Res 18:162-72

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