? ? This new application seeks funding for a multi-disciplinary research training program in Pulmonary Host Defense, Inflammation and Immunity at Case Western Reserve University School of Medicine and Health for pre-doctoral Ph.D. or M.D./Ph.D. students engaged in thesis work and for medical students engaged in shortterm research training. Presently, the research programs of Case faculty and the training programs for postdoctoral fellows and junior faculty in pulmonary host defense and in immunobiology are strong, and many pre-doctoral graduate and medical students are interested in joining these programs. There is a clear need for enlarging this pulmonary host defense community to include these students who are at earlier stages of their career, both to excite them about pursuing research careers in lung disease and to provide them outstanding training opportunities in inflammation and immunity. The objectives of this research training program are to 1) include these young students in this community, 2) provide outstanding multi-disciplinary research training and a rigorous background in pulmonary physiology in health and disease, 3) facilitate interactions that apply newly emerging information about basic mechanisms of inflammation and immunity to pulmonary disease, 4) develop new effective mentoring programs, and 5) provide an infrastructure. Our goals are to provide outstanding collaborative multidisciplinary research training to prepare our trainees for successful careers in pulmonary host defense and immunobiology, to train research and physician scientists to translate findings freely between the basic and clinical spheres, and to provide excellent mentor- and co-mentorship, which itself is taught to our trainees and evaluated by them. Short-term training for medical students will provide them an opportunity to pursue an area of research in greater depth than is accomplished within the traditional curriculum and increase awareness of opportunities in research through well structured, mentored research experiences that lay the foundation for future involvement in research. The outstanding, highly interactive 36 program faculty are based in 13 departments and have primary interests in four areas: lung immunobiology, tuberculosis, mechanisms of inflammation and innate immunity, or mucosal immunity. Thus, students will have opportunities through co-mentorship to learn about forefront advances in basic mechanisms in inflammation and immunity and to apply these to address important questions in lung biology. Underrepresented minorities are specifically recruited to join this program. Our evaluation system allows us to continuously improve our training program, and our database tracks the careers of these trainees. (End of Abstract) ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL083823-02
Application #
7290325
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Colombini-Hatch, Sandra
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$172,945
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Tomalka, Amanda G; Zmina, Stephanie E; Stopford, Charles M et al. (2013) Dimerization of the Pseudomonas aeruginosa translocator chaperone PcrH is required for stability, not function. J Bacteriol 195:4836-43
Strainic, Michael G; Shevach, Ethan M; An, Fengqi et al. (2013) Absence of signaling into CD4? cells via C3aR and C5aR enables autoinductive TGF-?1 signaling and induction of Foxp3? regulatory T cells. Nat Immunol 14:162-71
Simmons, Daimon P; Wearsch, Pamela A; Canaday, David H et al. (2012) Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing. J Immunol 188:3116-26
Tomalka, Amanda G; Stopford, Charles M; Lee, Pei-Chung et al. (2012) A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function. Mol Microbiol 86:1464-81
Janocha, Allison J; Koch, Carl D; Tiso, Mauro et al. (2011) Nitric oxide during altitude acclimatization. N Engl J Med 365:1942-4
Simmons, Daimon P; Canaday, David H; Liu, Yi et al. (2010) Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9. J Immunol 185:2405-15
Lee, Pei-Chung; Stopford, Charles M; Svenson, Amanda G et al. (2010) Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol 75:924-41
Drawz, Sarah M; Bethel, Christopher R; Hujer, Kristine M et al. (2009) The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276. Biochemistry 48:4557-66