Arterial thrombosis is frequently the proximate cause of death and morbidity in cardiovascular diseases, the leading cause of death in the Western World. The applicants propose to continue an interdisciplinary training program for post-doctoral scientists in the areas of blood cells in hemostasis, thrombosis, and vascular biology to be a centerpiece in an Initiative in Vascular Biology at the University of California San Diego, La Joll Campus. Most faculty members are internationally recognized investigator in the development and functioning of blood and vascular cells or in bioinformatic and biophysical tools applied to the study of such cells. Each faculty member has a strong track record of peer-reviewed research support and senior faculty has extensive track records in post-doctoral training. The faculty has interacted extensively through the mechanisms of collaboration and through program projects focused on Vascular Biology and Hemostasis-thrombosis. The interdisciplinary nature of the program is established by the faculty primary appointments in Multiple University Departments including, Cellular and Molecular Medicine (JDE,DT), Biology (DT,JYW), pathology (DC), Physics (AG), Pharmacology (TR), and Medicine (SJS, JAV, TI, TR, JYW, &MHG). The core of the program will be through performance of research in faculty laboratories spanning the disciplines of signal transduction, gene regulation, hematopoiesis, angiogenesis, and the molecular and cell biology of cells of the blood and vessel wall. This training program will provide a unique interdisciplinary educational opportunity to mentor outstanding scientists for research careers in the cellular basis of hemostasis, thrombosis, and vascular biology and will form the only active training program at UCSD directly devoted to this health-related field.

Public Health Relevance

Arterial thrombosis is frequently the proximate cause of death and morbidity in cardiovascular diseases, the leading cause of death in the Western World. This interdisciplinary training program will prepare both M.D. and Ph.D. scientists for careers in both basic and translational research into these diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL086344-06A1
Application #
8739128
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
2007-01-01
Project End
2019-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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