Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of many of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies in proteomics/genomics, hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a pool of approximately 20 to 30 postdoctoral fellows based on their academic potential and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will be required to participate in multidisciplinary journal clubs, a course on coagulation, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. Pediatric Hematology/Oncology trainees will be expected to meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre- existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.
The goal of the Training in Developmental Hematology Program is to train postdoctoral fellows in innovative basic, translational, and clinical research. Training future leaders and researchers in the field of Pediatric Hematology will advance our knowledge of Pediatric Hematologic diseases. This will lead to improved treatment and overall quality of life in children with blood diseases.
|Dou, Diana R; Calvanese, Vincenzo; Sierra, Maria I et al. (2016) Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol 18:595-606|
|Casero, David; Sandoval, Salemiz; Seet, Christopher S et al. (2015) Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol 16:1282-91|
|RodrÃguez-MalavÃ©, Norma I; Fernando, Thilini R; Patel, Parth C et al. (2015) BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer 14:214|
|Arenzana, Teresita L; Schjerven, Hilde; Smale, Stephen T (2015) Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev 29:1801-16|
|Nixon, Christopher C; Schwartz, Brandon H; Dixit, Dhaval et al. (2015) Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Sci Rep 5:8670|
|Baldwin, Kismet; Urbinati, Fabrizia; Romero, Zulema et al. (2015) Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy. Stem Cells 33:1532-42|
|Kim, William S; Zhu, Yuhua; Deng, Qiming et al. (2014) Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells 32:1503-14|
|Kohn, Lisa A; Seet, Christopher S; Scholes, Jessica et al. (2014) Human lymphoid development in the absence of common Î³-chain receptor signaling. J Immunol 192:5050-8|
|Magnusson, Mattias; Sierra, Maria I; Sasidharan, Rajkumar et al. (2013) Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability. PLoS One 8:e53912|
|Chang, Vivian Y; Federman, Noah; Martinez-Agosto, Julian et al. (2013) Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome. Pediatr Blood Cancer 60:570-4|
Showing the most recent 10 out of 15 publications