Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Understanding remains incomplete on the molecular pathogenesis of most of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to produce the cadre of investigators who will continue to advance the field. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation and gene therapy, hemostasis and thrombosis, transfusion medicine, novel technologies (genomics, proteomics, gene editing, etc.), hematologic malignancies, therapeutics, and bioinformatics. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either recent recipients of MD, MD/PhD, or PhD degrees undergoing postdoctoral training. We will emphasize recruitment to reflect the gender, racial, and ethnic diversity of our nation. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories that bridge 12 Departments, providing trainees access to the incredibly diverse academic assets across the UCLA campus. The mentoring faculty have active and productive research programs and multiple mutual collaborations and publications, providing an ideal training environment. Trainees may also participate in an exchange program established with the NHLBI-funded T32 program at the University of Michigan (HL007622) to gain deeper knowledge of either hemostasis/thrombosis or hematopoietic stem cell transplantation, two academic strengths of their program (UM trainees may come to UCLA for training in cell and gene therapy). Trainees will be selected from a large pool of postdoctoral fellows based on their academic and research achievements. Appointments will be for 1-2 years, the second year appointment dependent on documented productivity. Trainees will take a required course on Developmental Hematology and receive training in principles of human subject research and the responsible conduct of research through courses in research ethics. They will participate in journal clubs and attend seminars and lectures related to pediatric hematology, stem cell biology, immunology and clinical research. Trainees will meet with a Scholarship Oversight Committee every 6 months to monitor progress and productivity. We will utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.

Public Health Relevance

The goal of the Training in Developmental hematology Program is to train postdoctoral fellows in innovative basic, translational, and clinical research. Training future leaders and researchers in the field of Pediatric Hematology will advance our knowledge of Pediatric Hematologic diseases. This new understanding will lead to improved treatment and overall quality of life for children (and adults) with blood diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL086345-11
Application #
9417917
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
2007-04-01
Project End
2023-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Fernando, Thilini R; Contreras, Jorge R; Zampini, Matteo et al. (2017) The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia. Mol Cancer 16:126
Douaisi, Marc; Resop, Rachel S; Nagasawa, Maho et al. (2017) CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus. J Immunol 198:2310-2319
Upadhyay, Shivani Y; De Oliveira, Satiro N; Moore, Theodore B (2017) Use of Rapamycin in a Patient With Juvenile Myelomonocytic Leukemia: A Case Report. J Investig Med High Impact Case Rep 5:2324709617728528
Resop, Rachel S; Douaisi, Marc; Craft, Joshua et al. (2016) Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery. J Allergy Clin Immunol 138:551-557.e8
Dou, Diana R; Calvanese, Vincenzo; Sierra, Maria I et al. (2016) Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol 18:595-606
King, Jennifer K; Ung, Nolan M; Paing, May H et al. (2016) Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a. Front Immunol 7:670
Baldwin, Kismet; Urbinati, Fabrizia; Romero, Zulema et al. (2015) Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy. Stem Cells 33:1532-42
Rodríguez-Malavé, Norma I; Fernando, Thilini R; Patel, Parth C et al. (2015) BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer 14:214
Casero, David; Sandoval, Salemiz; Seet, Christopher S et al. (2015) Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol 16:1282-91
Nixon, Christopher C; Schwartz, Brandon H; Dixit, Dhaval et al. (2015) Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Sci Rep 5:8670

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