This is a resubmission application of the first competing renewal application of a training program that seeks funding to support predoctoral, postdoctoral, as well as clinical trainees in a multidisciplinary research program spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science with special emphasis in cardiovascular and vascular diseases. During the last funding cycle, we have been highly successful in expanding our training program from 25 faculty four years ago to 31 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Through the training program, we have been successful in establishing the Physician Scientist track (2+2) program for cardiology fellowship at UC Davis. Two predoctoral trainees have graduated and are now continuing their training as postdoctoral researchers. One postdoctoral trainee has been promoted to a junior faculty position. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The goal of the Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. By merging clinician scientist trainees together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to produce new Ph.D.s and postdoctoral/clinician scientists who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions/problems into clinically germane answers and solutions. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB) and Biomedical Engineering (BME), a truly multidisciplinary program. The training program includes required core courses, Summer School, Journal Clubs and Hot Topics in Translational Cardiovascular Sciences, courses in Responsible Conduct of Research, Cardiovascular Symposium, Basic and Translational Learning Groups, courses in biostatistics and epidemiology, grant writing, and survival skills. The advantages of such an integrated program are vast and far reaching. Basic and clinical trainees can begin to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications as well as the generation of mechanistic hypotheses which can be tested at the fundamental level directly derived from clinical research.

Public Health Relevance

This goal of the Training Program is to produce a new blend of scientists and clinician scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL086350-06A1
Application #
8551105
Study Section
Special Emphasis Panel (ZHL1-CSR-F (F2))
Program Officer
Wang, Wayne C
Project Start
2006-12-01
Project End
2018-06-30
Budget Start
2013-07-18
Budget End
2014-06-30
Support Year
6
Fiscal Year
2013
Total Cost
$383,028
Indirect Cost
$36,327
Name
University of California Davis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Hwang, Sung Hee; Wagner, Karen; Xu, Jian et al. (2017) Chemical synthesis and biological evaluation of ?-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett 27:620-625
Holland, Erika B; Feng, Wei; Zheng, Jing et al. (2017) An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors. Toxicol Sci 155:170-181
Wagner, K; Lee, K S S; Yang, J et al. (2017) Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain 21:456-465
Gluck, Jessica M; Herren, Anthony W; Yechikov, Sergey et al. (2017) Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. PLoS One 12:e0185125
Zhang, Rui; Pessah, Isaac N (2017) Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A. Mol Pharmacol 91:428-436
Nieves-CintrĂ³n, Madeline; Syed, Arsalan U; Buonarati, Olivia R et al. (2017) Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep 7:14058
Sirish, Padmini; Ledford, Hannah A; Timofeyev, Valeriy et al. (2017) Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol 10:
Yuen, Garrick K; Galice, Samuel; Bers, Donald M (2017) Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes. J Mol Cell Cardiol 108:158-169
Zhang, Zheng; Ledford, Hannah A; Park, Seojin et al. (2017) Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, ?-actinin2 and filamin A. J Physiol 595:2271-2284
Frederich, Bert J; Timofeyev, Valeriy; Thai, Phung N et al. (2017) Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm 14:1685-1692

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