This predoctoral training grant will support the multidisciplinary research training of graduate students for careers as independent investigators conducting research in cardiovascular and/or pulmonary diseases. Faculty advisors are investigators trained in various disciplines including: Physiology, Pharmacology, Biochemistry, Cell Biology, Neurobiology, Microbiology, Immunology, Exercise Science, Genetics, Molecular Biology, Internal Medicine, Cardiology and Pulmonology. Training faculty also include established scientists at the National Institute for Occupational Safety &Health (NIOSH), known for its research on inflammation and lung diseases. NIOSH is a research division of the CDC immediately adjacent to the School of Medicine. Most training faculty are members of either the (1) Center for Cardiovascular Research or (2) Center for Respiratory Biology &Lung Disease Research. The initial period of predoctoral training will emphasize courses which include Cell Biology, Biochemistry, Physiology, Molecular Biology, Statistics and Genomic Sciences as well as training in Scientific Integrity &Ethics. This first year of graduate work is organized as an integrated, core curriculum coupled with advanced literature-based graduate elective modules in the 2nd semester, which provides a solid foundation for advanced graduate courses and research. Students select a doctoral dissertation advisor by the end of their first year, based on laboratory research rotations. Thereafter, students pursue research under the supervision of their mentor, in addition to taking selective advanced graduate courses, attending seminars, participating in journal clubs, writing their PhD thesis proposals and presenting data at national meetings. Areas of research training include endothelial cell biology, inflammation induced vascular injury, microvascular physiology, cardiac pathobiology, airway and vascular reactivity, lung epithelial pathology, vascular smooth muscle biology, gene expression and lipids, ischemia-reperfusion, reactive oxygen radicals, cell signaling pathways, vascular remodeling, and angiogenesis, to name a few. Disease relevance of trainee projects are numerous;eg. coronary ischemia, asthma, pulmonary edema, hypertension, cardiac failure, intestinal vascular inflammation, pulmonary fibrosis, peripheral vascular disease, etc. Our interactive research environment, enhanced by Interdisciplinary Research Centers provides an ideal setting for cross fertilization of ideas, constructive criticism, and training of both Ph.D., and M.D./Ph.D. students for careers as investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL090610-05
Application #
8282770
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
2008-07-01
Project End
2014-10-31
Budget Start
2012-07-01
Budget End
2014-10-31
Support Year
5
Fiscal Year
2012
Total Cost
$322,750
Indirect Cost
$17,684
Name
West Virginia University
Department
Physiology
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
DeVallance, E; Fournier, S; Lemaster, K et al. (2016) The effects of resistance exercise training on arterial stiffness in metabolic syndrome. Eur J Appl Physiol 116:899-910
Shepherd, Danielle L; Nichols, Cody E; Croston, Tara L et al. (2016) Early detection of cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging. J Mol Cell Cardiol 90:74-83
Fournier, Sara B; Donley, David A; Bonner, Daniel E et al. (2015) Improved arterial-ventricular coupling in metabolic syndrome after exercise training: a pilot study. Med Sci Sports Exerc 47:2-11
DeVallance, E; Fournier, S B; Donley, D A et al. (2015) Is obesity predictive of cardiovascular dysfunction independent of cardiovascular risk factors? Int J Obes (Lond) 39:244-53
Nichols, Cody E; Shepherd, Danielle L; Knuckles, Travis L et al. (2015) Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter. Am J Physiol Heart Circ Physiol 309:H2017-30
Hindman, Bridget; Goeckeler, Zoe; Sierros, Kostas et al. (2015) Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells. PLoS One 10:e0131920
Zaccone, Eric J; Goldsmith, W Travis; Shimko, Michael J et al. (2015) Diacetyl and 2,3-pentanedione exposure of human cultured airway epithelial cells: Ion transport effects and metabolism of butter flavoring agents. Toxicol Appl Pharmacol 289:542-9
Thapa, Dharendra; Nichols, Cody E; Lewis, Sara E et al. (2015) Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction. J Mol Cell Cardiol 79:212-23
Fancher, Ibra S; Butcher, Joshua T; Brooks, Steven D et al. (2015) Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle. Microcirculation 22:315-25
Stapleton, Phoebe A; Nichols, Cody E; Yi, Jinghai et al. (2015) Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure. Nanotoxicology 9:941-51

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