This T-32 Training application is anchored within the Indiana University School of Medicine, the principal School of the Indiana University Purdue University at Indianapolis (lUPUI). The proposed training program in Lung Immunobiology is provided by a multidisciplinary, highly collaborative group of established investigators and highly qualified and dedicated mentors. We have included in the training program classical elements of basic and clinical-translational, research, adding on developing novel technologies. These research skills will enable our trainees to accelerate the advancements in lung research and close the gaps in knowledge that prevented for so many decades the development of phenotypic characterization, effective preventive intervention, and disease- modifying or even curative druts for most patients with lung disease. Being led by Program Director who is a renowned physician scientist and experienced mentor who himself is a minority, and having direct support from an experienced Minority Advisory Board, this application demonstrates our commitment to the development of a successful training program for under-represented and minority scientists. The Program Director will obtain continuous advise and feedback regarding the operation of the Training Grant from several internal and one external committee, composed of leaders in academic medicine If funded, this program will provide the only research training program of pulmonary physicians and scientists in the state of Indiana, which has one of the highest incidence of chronic lung diseases in the country.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL091816-05
Application #
8442828
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
5
Fiscal Year
2013
Total Cost
$80,744
Indirect Cost
$13,110
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Glosson-Byers, Nicole L; Sehra, Sarita; Stritesky, Gretta L et al. (2014) Th17 cells demonstrate stable cytokine production in a proallergic environment. J Immunol 193:2631-40
Pham, Duy; Yu, Qing; Walline, Crystal C et al. (2013) Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol 191:902-11
Lahm, Tim; Albrecht, Marjorie; Fisher, Amanda J et al. (2012) 17ýý-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med 185:965-80
Yu, Qing; Zhou, Baohua; Zhang, Yanlu et al. (2012) DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation. Proc Natl Acad Sci U S A 109:541-6
Schweitzer, Kelly S; Johnstone, Brian H; Garrison, Jana et al. (2011) Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med 183:215-25
Shahda, S; Carlos, W G; Kiel, P J et al. (2011) The human metapneumovirus: a case series and review of the literature. Transpl Infect Dis 13:324-8
Schweitzer, Kelly S; Hatoum, Hadi; Brown, Mary Beth et al. (2011) Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides. Am J Physiol Lung Cell Mol Physiol 301:L836-46