This T-32 Training application is anchored within the Indiana University School of Medicine, the principal School of the Indiana University Purdue University at Indianapolis (lUPUI). The proposed training program in Lung Immunobiology is provided by a multidisciplinary, highly collaborative group of established investigators and highly qualified and dedicated mentors. We have included in the training program classical elements of basic and clinical-translational, research, adding on developing novel technologies. These research skills will enable our trainees to accelerate the advancements in lung research and close the gaps in knowledge that prevented for so many decades the development of phenotypic characterization, effective preventive intervention, and disease- modifying or even curative druts for most patients with lung disease. Being led by Program Director who is a renowned physician scientist and experienced mentor who himself is a minority, and having direct support from an experienced Minority Advisory Board, this application demonstrates our commitment to the development of a successful training program for under-represented and minority scientists. The Program Director will obtain continuous advise and feedback regarding the operation of the Training Grant from several internal and one external committee, composed of leaders in academic medicine If funded, this program will provide the only research training program of pulmonary physicians and scientists in the state of Indiana, which has one of the highest incidence of chronic lung diseases in the country.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Khan, Sikandar H; Kitsis, Michelle; Golovyan, Dmitriy et al. (2018) Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature. Heart Lung 47:489-496
Khan, Sikandar; Biju, Ashok; Wang, Sophia et al. (2018) Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. Trials 19:94
Golovyan, Dmitriy M; Khan, Sikandar H; Wang, Sophia et al. (2018) What should I address at follow-up of patients who survive critical illness? Cleve Clin J Med 85:523-526
Ni, Kevin; Gill, Amar; Tseng, Victor et al. (2018) Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res 19:107
Wang, Sophia; Hammes, Jessica; Khan, Sikandar et al. (2018) Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial. Trials 19:196
Khan, Sikandar H; Devnani, Rohit; LaPradd, Michelle et al. (2018) Age of transfused red blood cells and health outcomes in two surgical cohorts. Heart Lung :
Frump, Andrea L; Selej, Mona; Wood, Jordan A et al. (2018) Hypoxia Upregulates Estrogen Receptor ? in Pulmonary Artery Endothelial Cells in a HIF-1?-Dependent Manner. Am J Respir Cell Mol Biol 59:114-126
Khan, Sikandar H; Wang, Sophia; Harrawood, Amanda et al. (2017) Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. Trials 18:574
Brown, Mary Beth; Neves, Evandro; Long, Gary et al. (2017) High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol 312:R197-R210
Wang, Sophia; Mosher, Chris; Perkins, Anthony J et al. (2017) Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life. J Hosp Med 12:831-835

Showing the most recent 10 out of 31 publications