This application requests funding for a highly interdisciplinary, translational postdoctoral training program focused on inflammation and infection in the development and progression of cardiovascular disease (CVD). Inflammation and infection are receiving increasing attention in the pathophysiology of CVD, yet few groups have assembled that combine expertise in the diverse aspects of inflammation and infection focused on CVD. This innovative program is housed in the Biotechnology and Bioengineering Center (BBC) at the Medical College of Wisconsin because of its central focus on translation of basic science discoveries and technological innovations to disease and clinical medicine. We have formed a unique group of highly qualified academic, industrial, and clinical partners dedicated to outstanding mentoring of postdoctoral trainees in teams. This focused (1 M.D. and 2 Ph.D.) program of 2-3 years duration per trainee will be part of the ongoing fellowship program in the BBC. Our training team members are unified in their belief that contemporary fellowship programs must not only give young scientists an outstanding experience at the bench, but must also provide intensive exposure to a variety of technologies and approaches. Most importantly, young scientists need mentoring that extends beyond the traditional postdoc-mentor relationship. Our diverse colleague network includes not only senior mentors and technical experts (academic consultants), but also junior faculty and peers. This network will provide the most important building blocks for optimal professional development, encompassing an appropriate balance between challenges and support, constructive feedback, overall guidance, providing confidence and emotional support, and building friendships. The training combines an individualized mentoring program via mentoring teams with an individual development plan for each trainee. Mentors include outstanding basic scientists from traditional and non-traditional areas, clinical scientists focused on infection and inflammation in CVD, and representatives from industry to advise our fellows on technology transfer, non-academic career options, and to provide an outside viewpoint on their research. Fellows will be recruited nationally and selected on the basis of academic credentials, research experience, and a commitment to a career in research and training. Training will combine traditional laboratory-based inquiry, short courses, seminars and clinical correlations. Concepts of science management, industrial research and development, technology transfer, patents, and ethics will be explored. Trainees will initially rotate through labs in the BBC to become familiar with capabilities of Genomic and Proteomic technology platforms.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094273-04
Application #
8255619
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
4
Fiscal Year
2012
Total Cost
$174,014
Indirect Cost
$12,638
Name
Medical College of Wisconsin
Department
Physiology
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Moxley, Michael A; Beard, Daniel A; Bazil, Jason N (2016) Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum. J Biol Chem 291:2712-30
Prisco, Anthony R; Hoffmann, Brian R; Kaczorowski, Catherine C et al. (2016) Tumor Necrosis Factor α Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. Stem Cells 34:1922-33
Neuner, Sarah M; Wilmott, Lynda A; Hope, Kevin A et al. (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281:69-77
Moxley, Michael A; Beard, Daniel A; Bazil, Jason N (2014) A pH-dependent kinetic model of dihydrolipoamide dehydrogenase from multiple organisms. Biophys J 107:2993-3007
Prisco, Anthony R; Bukowy, John D; Hoffmann, Brian R et al. (2014) Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. PLoS One 9:e94599
Hoffmann, Brian R; Wagner, Jordan R; Prisco, Anthony R et al. (2013) Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress. Physiol Genomics 45:1021-34
Kaczorowski, Catherine C; Stodola, Timothy J; Hoffmann, Brian R et al. (2013) Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. Physiol Genomics 45:999-1011
Bazil, Jason N; Vinnakota, Kalyan C; Wu, Fan et al. (2013) Analysis of the kinetics and bistability of ubiquinol:cytochrome c oxidoreductase. Biophys J 105:343-55
Bazil, Jason N; Blomeyer, Christoph A; Pradhan, Ranjan K et al. (2013) Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria. J Bioenerg Biomembr 45:177-88
Tewari, Shivendra G; Dash, Ranjan K; Beard, Daniel A et al. (2012) A biophysical model of the mitochondrial ATP-Mg/P(i) carrier. Biophys J 103:1616-25

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