This is a re-submission of a new application for an Institutional training grant to train pre-and post doctoral fellows at the University of Chicago in research related to O2 Biology in Health &Disease. Rationale: Understanding the mechanisms of O2 sensing and determinants of cellular O2 requirements are fundamental to many disease processes. Recent advances provided a paradigm shift in our understanding of how cells sense O2, and also spectacular insights into the molecular basis for how organisms adapt to changes in O2 environment. The translational potential of O2 biology attracted the attention of researchers in various disciplines of Biology &Medicine and there is an absolute need to provide research training in O2 biology to the next generation of basic and physician scientists. The goals of the program are a) to provide trainees with a broad foundation in the O2 biology in the areas of O2 sensing, O2 Patho-biology, Ischemia-Reperfusion, and Biology of reactive oxygen species and b) to prepare trainees to pursue competitive careers in basic and/or clinical research, teaching in academia and/or the biotechnology field. The proposed faculty members have established research programs in one or more areas of O2 biology and have trained a number of successful scientists. The training faculty represents 5 clinical and 3 basic science departments. This training program is built upon existing collaborations amongst the proposed faculty and fosters training through collaborative research related to O2 biology. We request 2 pre-doctoral and 5 post-doctoral positions. The pre-doctoral trainees will be recruited from one or more of the Ph.D. awarding committees, and Post-doctoral trainees recruWed will include: 1) Ph.D. post-doctoral trainees, 2) MDs recruited in clinical fellowship programs in Medicine, Pediatrics, Surgery, Radiation-oncology, and Anesthesia and 3) MD-Ph.D.s recruited into the Physician-Scientist Development Program in the Department of Medicine. Both pre-and post doctoral trainees will be offered an interdisciplinary course in O2 Biology along with core curriculum, seminars and Journal clubs. In addition to research, training in grants-manship and writing skills will be offered enabling them to become independent scientists. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, will develop well-rounded scientists trained in O2 biology, which has basic and translational significance.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094282-04
Application #
8279310
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
2009-06-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$263,157
Indirect Cost
$17,123
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Applebaum, Mark A; Jha, Aashish R; Kao, Clara et al. (2016) Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget 7:76816-76826
Jha, Aashish R; Zhou, Dan; Brown, Christopher D et al. (2016) Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol 33:501-17
Boland, Brandon B; Alarcón, Cristina; Ali, Almas et al. (2015) Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets. Islets 7:e1073435
Jha, Aashish R; Miles, Cecelia M; Lippert, Nodia R et al. (2015) Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster. Mol Biol Evol 32:2616-32
Rizk, Rania S; Discipio, Katherine A; Proudfoot, Kathleen G et al. (2014) The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization. J Cell Biol 204:965-75
Cassidy, Justin J; Jha, Aashish R; Posadas, Diana M et al. (2013) miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell 155:1556-67
Shelat, Phullara B; Plant, Leigh D; Wang, Janice C et al. (2013) The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis. J Neurosci 33:12287-99
Chen, Yue; Colak, Gozde; Zhao, Yingming (2013) SILAC-based quantification of Sirt1-responsive lysine acetylome. Methods Mol Biol 1077:105-20
Carreras, Alba; Kayali, Foaz; Zhang, Jing et al. (2012) Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period. Am J Physiol Regul Integr Comp Physiol 303:R700-9
Entwistle, Ruth A; Rizk, Rania S; Cheng, Daniel M et al. (2012) Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem 7:1580-6

Showing the most recent 10 out of 12 publications