This renewal application is to continue supporting our successful Pulmonary Genetic Medicine Training Program for postdoctoral fellows at Weill Cornell Medical College (WCMC) that will complete its first five-year period of funding by NHLBI August 31, 2014. The Pulmonary Genetic Medicine Training Program is an inter-departmental and inter-institutional collaborative effort with a faculty of experienced investigators at WCMC and Memorial Sloan-Kettering Cancer Center (MSKCC). The goal of the Training Program is still to provide MD, PhD and MD/PhD trainees interested in pulmonary biology and medicine with a multi-disciplinary training in genomics and gene expression, gene therapy, stem cells, metabolomics, statistical genetics and computational science, epidemiology, ethics and regulatory affairs. The Training Program will continue to support 6 postdoctoral trainees, each for up to 3 years. Under the direction of Ronald G. Crystal, Professor and Chairman of the Department of Genetic Medicine, the Program has grown and currently incorporates 26 faculty members. Dr. Crystal will continue to be assisted by 4 Associate Directors, an internal Executive Committee, a Committee on Recruitment and Retention, and an External Advisory Committee. In addition, Fernando Martinez, Professor of Medicine, will be Deputy Director to assist Dr. Crystal in management of the program. In the past 5 years, we have recruited 12 trainees for 6 postdoctoral slots. To date, the 12 trainees have published 45 peer-reviewed papers including 17 first-authored. They all had the opportunity to present their research (28 first-author abstracts) at national and international conferences. Of the 12 trainees, 4 have gone on to junior faculty positions, 2 have gone back to finish clinical training and 6 have continued in post-doctoral training. Of the 4 at the faculty level, 1 successfully obtained a grant from the National Foundation for Cancer Research, 1 has applied for a NIH Mentored Research Scientist Development Award (K01) and 2 are currently working on a grant submission to the NIH. Among the 12 trainees, 1 was from an underrepresented minority of Hispanic origin, now a faculty member, 3 are of Asian ancestry and 6 are women. Besides the existing educational opportunities that were in place at WCMC and MSKCC at the time of the first cycle submission, we instituted a highly successful Pulmonary Genetic Medicine Didactic Course created for our trainees, open for the entire WCMC and MSKCC communities. This renewal proposal seeks continued support for the growth of the Pulmonary Genetic Medicine Training Program.

Public Health Relevance

. The focus of the Weill Cornell Pulmonary Genetic Medicine Training Program is to train MD, MD/PhD and PhD post-doctoral fellows to perform research that provides an understanding of the relationship between the genome, the environment and the risk for pulmonary disease. The ulti- mate goal is to translate that knowledge into future personalized, genetic medicine therapies for lung diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL094284-06A1
Application #
8935374
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
2009-02-01
Project End
2020-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
6
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Genetics
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
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O'Beirne, Sarah L; Shenoy, Sushila A; Salit, Jacqueline et al. (2018) Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome. Am J Respir Crit Care Med 198:1413-1422
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Ginsberg, Michael; Schachterle, William; Shido, Koji et al. (2015) Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Nat Protoc 10:1975-85
1000 Genomes Project Consortium; Auton, Adam; Brooks, Lisa D et al. (2015) A global reference for human genetic variation. Nature 526:68-74

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