This continuation proposal seeks funds for a training program in translational research applied to cardiovascular disease. The program recruits PhD and MD trainees through the Division of Cardiovascular Medicine at Oregon Health &Science University and the Heart Research Center. Six post-doctoral fellows per year are offered funding for two years of research training. The program offers exciting opportunities for bench to bedside training in one of three established groups that specialize in 1) obesity/diabetes, 2) developmental programming, and 3) regulatory processes. The 28 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training includes molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, bioengineering vascular elements, mathematical models of cardiovascular dysregulation. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. All trainees participate in Responsible Conduct of Research training and team science methods. This program is unique at OHSU in that mentoring is carried out in a team approach and because this training program is specifically designed to translate basic research into clinical benefit. A basic scientist and a clinical scientist plus on additional scientist serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. The scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity.

Public Health Relevance

This proposed program will address the urgent need for cardiovascular scientists who are trained broadly in translational sciences focused on cardiovascular disease. The program will train 30 scientists who will join the ranks of academia and promote cutting edge research in heart disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL094294-06A1
Application #
8742784
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Carlson, Drew E
Project Start
2008-07-01
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Wu, Melinda D; Atkinson, Tamara M; Lindner, Jonathan R (2017) Platelets and von Willebrand factor in atherogenesis. Blood 129:1415-1419
Belcik, J Todd; Davidson, Brian P; Xie, Aris et al. (2017) Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling. Circulation 135:1240-1252
Vatankhah, Nasibeh; Jahangiri, Younes; Landry, Gregory J et al. (2017) Effect of systemic insulin treatment on diabetic wound healing. Wound Repair Regen 25:288-291
Denfeld, Quin E; Winters-Stone, Kerri; Mudd, James O et al. (2017) The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int J Cardiol 236:283-289
Denfeld, Quin E; Winters-Stone, Kerri; Mudd, James O et al. (2017) Frequency of and Significance of Physical Frailty in Patients With Heart Failure. Am J Cardiol 119:1243-1249
Vatankhah, Nasibeh; Jahangiri, Younes; Landry, Gregory J et al. (2017) Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing. J Vasc Surg 65:478-483
Zuloaga, Kristen L; Johnson, Lance A; Roese, Natalie E et al. (2016) High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion. J Cereb Blood Flow Metab 36:1257-70
Nelson, Jonathan W; Das, Anjali J; Barnes, Anthony P et al. (2016) Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes. PLoS One 11:e0152742
Nelson, Jonathan W; Sklenar, Jiri; Barnes, Anthony P et al. (2016) The START App: a web-based RNAseq analysis and visualization resource. Bioinformatics :
Olivas, Antoinette; Gardner, Ryan T; Wang, Lianguo et al. (2016) Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130. J Neurosci 36:479-88

Showing the most recent 10 out of 59 publications