This continuation proposal seeks funds for a training program in translational research applied to cardiovascular disease. The program recruits PhD and MD trainees through the Division of Cardiovascular Medicine at Oregon Health &Science University and the Heart Research Center. Six post-doctoral fellows per year are offered funding for two years of research training. The program offers exciting opportunities for bench to bedside training in one of three established groups that specialize in 1) obesity/diabetes, 2) developmental programming, and 3) regulatory processes. The 28 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training includes molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, bioengineering vascular elements, mathematical models of cardiovascular dysregulation. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. All trainees participate in Responsible Conduct of Research training and team science methods. This program is unique at OHSU in that mentoring is carried out in a team approach and because this training program is specifically designed to translate basic research into clinical benefit. A basic scientist and a clinical scientist plus on additional scientist serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. The scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity.
This proposed program will address the urgent need for cardiovascular scientists who are trained broadly in translational sciences focused on cardiovascular disease. The program will train 30 scientists who will join the ranks of academia and promote cutting edge research in heart disease.
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|Gong, Qiuming; Stump, Matthew R; Zhou, Zhengfeng (2014) Upregulation of functional Kv11.1 isoform expression by inhibition of intronic polyadenylation with antisense morpholino oligonucleotides. J Mol Cell Cardiol 76:26-32|
|Inaba, Yoichi; Davidson, Brian P; Kim, Sajeevani et al. (2014) Echocardiographic evaluation of the effects of stem cell therapy on perfusion and function in ischemic cardiomyopathy. J Am Soc Echocardiogr 27:192-9|
|Gong, Qiuming; Stump, Matthew R; Zhou, Zhengfeng (2014) Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome. Gene 539:190-7|
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|Gong, Qiuming; Stump, Matthew R; Deng, Vivianne et al. (2014) Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome. Circ Cardiovasc Genet 7:482-90|
|Ryu, Jae Choon; Davidson, Brian P; Xie, Aris et al. (2013) Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. Circulation 127:710-9|
|Liu, Yani; Davidson, Brian P; Yue, Qi et al. (2013) Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging 6:74-82|
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