Acute and chronic lung diseases are major causes of morbidity and mortality throughout the world. For many of these diseases, the fundamental pathobiology is not well understood and effective, disease-modifying treatments are not available. Therefore, there is a pressing need to train researchers focused on elucidating disease mechanisms. The Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University and the Center for Lung Research have a long, successful history in developing well trained researchers who have the vision and the skills with which to embark on successful careers in academic research. This new program will train young investigators to study basic mechanisms of lung inflammation, repair, and remodeling. The Vanderbilt Center for Lung Research (VCLR), which was developed to coordinate and enhance collaborative interdisciplinary research and training related to the lungs, will house this program, and Dr. Timothy Blackwell (director of the VCLR) will serve as program director. This training program will support postdoctoral trainees who have completed M.D. and/or Ph.D. programs and show exceptional aptitude for successfully pursuing an academic research career. Trainees will concentrate on one of several disease focused areas of existing expertise in the VCLR: acute lung inflammation/injury, asthma, pulmonary fibrosis, pulmonary hypertension, or lung carcinogenesis. A customized mentoring team will be formed for each trainee, consisting of a mentor with nationally recognized expertise in the area and a research advisory committee to provide additional guidance, mentoring, and feedback. The trainee's experience will be enhanced by interactions with other investigators and trainees in existing lung disease-focused research programs in the VCLR, an extensive program of seminars and conferences, and coursework tailored to meet the needs of each trainee. The unique environment of the VCLR - its rich collaborative interactions between basic scientists and clinical researchers, wide range of supporting Cores and Centers, and exposure to state-of-the-art clinical care - provides an outstanding opportunity to train successful scientists whose discoveries regarding fundamental aspects of lung diseases can be translated into improved patient care.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Peng, Hui; Zhang, Yixiang; Palmer, Lauren D et al. (2017) Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus. ACS Infect Dis 3:744-755
Polosukhin, Vasiliy V; Richmond, Bradley W; Du, Rui-Hong et al. (2017) Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling. Am J Respir Crit Care Med 195:1010-1021
Peng, Hui; Shen, Jiangchuan; Edmonds, Katherine A et al. (2017) Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus. mSphere 2:
Ichihara, Eiki; Westover, David; Meador, Catherine B et al. (2017) SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer. Cancer Res 77:2990-3000
Hawkins, Charlene; Shaginurova, Guzel; Shelton, D Auriel et al. (2017) Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. J Immunol Res 2017:3642832
Celada, Lindsay J; Rotsinger, Joseph E; Young, Anjuli et al. (2017) Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation. Am J Respir Cell Mol Biol 56:74-82
Kinsella, Rachel L; Lopez, Juvenal; Palmer, Lauren D et al. (2017) Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species. J Biol Chem 292:19628-19638
Richmond, Bradley W; Brucker, Robert M; Han, Wei et al. (2016) Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun 7:11240
McLoed, Allyson G; Sherrill, Taylor P; Cheng, Dong-Sheng et al. (2016) Neutrophil-Derived IL-1? Impairs the Efficacy of NF-?B Inhibitors against Lung Cancer. Cell Rep 16:120-132
Claar, Dru D; Larkin, Emma K; Bastarache, Lisa et al. (2016) A Phenome-Wide Association Study Identifies a Novel Asthma Risk Locus Near TERC. Am J Respir Crit Care Med 193:98-100

Showing the most recent 10 out of 67 publications