The Brown CardioPulmonary Training Program has as its overall objective the training of physicians and scientists who will become independent investigators in the molecular basis and pathobiology of cardiovascular and pulmonary diseases and the outcomes of prevention and treatment of these diseases. This will be accomplished by a rigorous program of didactic training and mentored research experience in a collaborative, multidisciplinary setting with career development training. Four postdoctoral trainees with an MD, PhD, or MD/PhD degree will be accepted per year into a 3- year research training program. Thirty-three experienced and well-funded faculty trainers plus seven promising junior faculty trainers from 11 academic departments have developed a Training Program that utilizes resources from 7 Brown teaching hospitals plus Brown University. The Training Program aims to bridge gaps between bio-medical, behavioral and public health disciplines to advance knowledge regarding how best to reduce disease burden among patients with diseases that affect the cardiovascular system and lungs. This will be accomplished by training in Molecular Pathobiology of Cardiovascular and Pulmonary Diseases or in Health Services/Outcomes. This Training Program is uniquely positioned to train individuals in research related to diseases that involve these systems, such as aging. Having trainees looking at these problems from both bench to bedside and bedside to practice aspects can lead to new insights, lines of synergistic research and advances in science using both molecular methods and epidemiologic, clinical trials, and health services investigations.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094300-03
Application #
7905834
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O2))
Program Officer
Commarato, Michael
Project Start
2008-09-01
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
3
Fiscal Year
2010
Total Cost
$549,680
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Kim, Tae Yun; Kofron, Celinda M; King, Michelle E et al. (2018) Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts. PLoS One 13:e0196714
Liang, Olin D; So, Eui-Young; Egan, Pamela C et al. (2017) Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension. Cardiovasc Res 113:1560-1573
Vang, Alexander; Clements, Richard T; Chichger, Havovi et al. (2017) Effect of ?7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol 312:L748-L759
Kofron, C M; Kim, T Y; King, M E et al. (2017) Gq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a three-dimensional microtissue environment. Am J Physiol Heart Circ Physiol 313:H810-H827
Wu, Keith Q; Muratore, Christopher S; So, Eui-Young et al. (2017) M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression. Am J Pathol 187:2102-2111
Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition modulates glycogen synthase kinase 3? pathways in ischemic myocardium: A proteomic and mechanistic analysis. J Thorac Cardiovasc Surg 153:342-357
Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. Surgery 161:1394-1404
Scrimgeour, Laura A; Potz, Brittany A; Elmadhun, Nassrene Y et al. (2017) Alcohol attenuates myocardial ischemic injury. Surgery 162:680-687
Kim, Tae Yun; Terentyeva, Radmila; Roder, Karim H F et al. (2017) SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR. Cardiovasc Res 113:343-353
Feng, Jun; Liu, Yuhong; Sabe, Ashraf A et al. (2016) Differential impairment of adherens-junction expression/phosphorylation after cardioplegia in diabetic versus non-diabetic patients. Eur J Cardiothorac Surg 49:937-43

Showing the most recent 10 out of 71 publications