The diagnosis and management of CV disease relies on non-invasive testing to enhance the identification of high risk patients and optimize management strategies. Molecular imaging is a key tool to improve risk assessment and lead to more individualized approaches to diagnosing and treating disease. Our objective is to produce CV imaging specialists with the clinical and investigative skills to establish independent careers, mentor others, and lead their own CV Imaging programs. We designed a comprehensive curriculum-based training program in multi-modality CV Imaging research that includes: (1) a 2-year training program in translational research taught by a multidisciplinary faculty of MD and/or PhD scientists;(2) an extended didactic clinical and basic science research curriculum consisting of orientation lectures;basic analytic and bioethics courses, advanced course work (including two program-specific advanced courses);and ongoing learning opportunities;and (3) a mentored clinical or translational research experience that includes formal training in research methodology, and the development of a research project including protocol development, experimental execution, critical data analysis, oral presentation, manuscript writing, and grant preparation. We seek NIH support for research training in imaging science for 2 fellows (MD or MD PhD) annually. Our program is opened to cardiologists, radiologists and other imaging specialists. We have assembled a group of 12 outstanding faculty mentors, each of whom are pursuing research at the cutting-edge of cardiac imaging science. Collectively, they have over 50 active extramural grants and have mentored over 170 pre/post doctoral fellows in various aspects of basic and clinical cardiac imaging research. Extensive collaboration among the faculty, trainees, and other investigators throughout the BWH, MGH, and Harvard Medical School communities, further increase the Program's scientific impact. We anticipate that our trainees will fulfill our overall objectives and that our graduates will disseminate CV Imaging training, ultimately creating a critical mass of imaging scientists to meet the health care needs of our population.

Public Health Relevance

There is a severe shortage of trained individuals with the knowledge and skills to bridge the gap between imaging technology and the evidence to support the use of such technology. The proposed training program is particularly valuable now that cardiovascular imaging has become the 'hot button'for policy makers because of its effect on costs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094301-04
Application #
8488465
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$315,018
Indirect Cost
$20,298
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Taqueti, Viviany R; Hachamovitch, Rory; Murthy, Venkatesh L et al. (2015) Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 131:19-27
Taqueti, Viviany R; Everett, Brendan M; Murthy, Venkatesh L et al. (2015) Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 131:528-35
Shah, Ravi V; Murthy, Venkatesh L; Abbasi, Siddique A et al. (2015) Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Prev Cardiol 22:1408-18
Gupta, Deepak K; Skali, Hicham; Claggett, Brian et al. (2014) Heart failure risk across the spectrum of ankle-brachial index: the ARIC study (Atherosclerosis Risk In Communities). JACC Heart Fail 2:447-54
Gupta, Deepak K; Skali, Hicham; Rivero, Jose et al. (2014) Assessment of myocardial viability and left ventricular function in patients supported by a left ventricular assist device. J Heart Lung Transplant 33:372-81
Abbasi, Siddique A; Heydari, Bobak; Shah, Ravi V et al. (2014) Risk stratification by regadenoson stress magnetic resonance imaging in patients with known or suspected coronary artery disease. Am J Cardiol 114:1198-203
Aguirre, Aaron D; Vinegoni, Claudio; Sebas, Matt et al. (2014) Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A 111:11257-62
Waller, Alfonso H; Blankstein, Ron; Kwong, Raymond Y et al. (2014) Myocardial blood flow quantification for evaluation of coronary artery disease by positron emission tomography, cardiac magnetic resonance imaging, and computed tomography. Curr Cardiol Rep 16:483
Gupta, Deepak K; Shah, Amil M; Giugliano, Robert P et al. (2014) Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48. Eur Heart J 35:1457-65
Blankstein, Ron; Osborne, Michael; Naya, Masanao et al. (2014) Cardiac positron emission tomography enhances prognostic assessments of patients with suspected cardiac sarcoidosis. J Am Coll Cardiol 63:329-36

Showing the most recent 10 out of 31 publications