This is a new application to fund Pulmonary research training at the University of Texas Southwestern Medical Center, at the postdoctoral (MD, PhD) level. The proposal is born out of a collaborative effort between the Pediatric and Adult divisions involved in lung research at this Institute, and is thus interdepartmental at its core. Twenty six funded, experienced investigators representing 12 different clinical and basic science departments and centers form a solid, diverse training force, organized into four thematic tracks: 1) Pulmonary vascular disease;2) Interstitial lung diseases;3) Lung epithelial cell and differentiation disorders;and 4) Immunity/Inflammation/Sepsis. Trainees will be paired with one of our mentors and enter one of these four tracks. Besides mentor-based teaching, trainees will receive a comprehensive track- and project-specific didactic curriculum. Both clinical and basic science trainees will be guided by an individualized advisory committee that has both basic and clinical science mentors, to broaden the trainee's perspective and facilitate bench to bedside thinking. Emphasis will be placed on maintenance of project focus, creative experimental design, state of the art technology, and careful early career guidance. The strength of this program lies in the highly collaborative Institutional environment, the unique interdepartmental leadership and training faculty of the program, and the experienced and dedicated faculty serving as trainers.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Colombini-Hatch, Sandra
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University of Texas Sw Medical Center Dallas
Internal Medicine/Medicine
Schools of Medicine
United States
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Tanigaki, Keiji; Sacharidou, Anastasia; Peng, Jun et al. (2018) Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance. J Clin Invest 128:309-322
Sacharidou, Anastasia; Shaul, Philip W; Mineo, Chieko (2018) New Insights in the Pathophysiology of Antiphospholipid Syndrome. Semin Thromb Hemost 44:475-482
Ochoa, Cristhiaan D; Wu, Ru Feng; Terada, Lance S (2018) ROS signaling and ER stress in cardiovascular disease. Mol Aspects Med 63:18-29
Sacharidou, Anastasia; Chambliss, Ken L; Ulrich, Victoria et al. (2018) Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. Blood 131:2097-2110
Adams, Traci; Newton, Chad; Patel, Hetal et al. (2018) Resident versus faculty member simulation debriefing. Clin Teach 15:462-466
Kasiri, Sahba; Shao, Chunli; Chen, Baozhi et al. (2017) GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Res 77:4448-4459
Maryoung, Lindley; Yue, Yangbo; Young, Ashley et al. (2017) Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations. J Clin Invest 127:982-986
Newton, Chad A; Kozlitina, Julia; Lines, Jefferson R et al. (2017) Telomere length in patients with pulmonary fibrosis associated with chronic lung allograft dysfunction and post-lung transplantation survival. J Heart Lung Transplant 36:845-853
Rowe, Regina K; Pyle, David M; Tomlinson, Andrew R et al. (2017) IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol 140:294-298.e8
Wu, Ru Feng; Liao, Chengxu; Hatoum, Hadi et al. (2017) RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras. Arterioscler Thromb Vasc Biol 37:98-107

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