This is the first competitive renewal of a currently funded T32 grant that provides post-doctoral training in multi-disciplinary multi-modality molecular and translational cardiovascular imaging for highly qualified fellows holding either a MD or/and PhD, in preparation for academic careers as independent investigators in the highly clinically relevant field of cardiovascular imaging. As imaging technology and molecular medicine advances, increasingly complex questions often arise requiring the convergence of perspectives from multiple disciplines. The future of cardiovascular imaging will most likely be practiced by integrated multidisciplinary teams with diverse areas of expertise. The goal of this research training program is to provide the necessary skills needed to work in this new multi-disciplinary investigative environment. Applicants will be recruited from both clinical and basic science departments, with particular attention paid to minority, disabled, and disadvantaged candidates. We will continue to select and enroll applicants in order to maintain support for 4 post-doctoral fellows each year, with an equal balance of physicians and scientists. Post-doctoral fellowship training will be 2-3 years in duration. There will be three primary research focuses in the post-doctoral training, 1) cardiovascular molecular imaging, 2) cardiovascular imaging technologies and analyses, and 3) translational cardiovascular imaging. The primary faculty for this program are from the Yale School of Engineering and Applied Sciences and from multiple departments within the Yale School of Medicine, including: Internal Medicine (Section of Cardiovascular Medicine), Diagnostic Radiology, Surgery, Anesthesiology, and Therapeutic Radiology. The faculty sponsors have been selected based on extramural support, research productivity, and commitment to multi-disciplinary training. Each trainee will be assigned both a basic science/engineering and clinical mentor. Trainee progress will be monitored by individual mentors, the trainee's advisory committee, and the Program Directors. Drs. Sinusas and Duncan will co-manage the program to assure a balanced and integrated experience in the relevant clinical and engineering sciences.

Public Health Relevance

Cardiovascular disease remains the major cause of death in the US, and although care is improving, the cost of such care exceeded $400 billion in 2008. Thus, there has been a shift in emphasis from treatment of disease to the prevention of disease. Prevention of cardiovascular disease necessitates early detection and risk stratification, which may be facilitated by molecular and other multimodality imaging approaches.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL098069-07
Application #
8986811
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Huang, Li-Shin
Project Start
2009-12-01
Project End
2020-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
Boutagy, Nabil E; Wu, Jing; Cai, Zhengxi et al. (2018) In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC Basic Transl Sci 3:378-390
Guerriero, Kathryn A; Wilson, Steven R; Boutagy, Nabil E et al. (2018) Cutaneous Toxicity in a Laboratory Beagle (Canis lupus familiaris) after Chronic Administration of Doxorubicin Hydrochloride. Comp Med 68:56-62
Mohy-Ud-Din, Hassan; Boutagy, Nabil E; Stendahl, John C et al. (2018) Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study. J Nucl Cardiol 25:2096-2111
Feher, Attila; Srivastava, Ajay; Quail, Michael A et al. (2018) Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovasc Imaging :
Boutagy, Nabil E; Sinusas, Albert J (2017) Imaging of the Cardiac Sympathetic Nervous System Has Potential Value in the Evaluation of Patients with Heart Failure with Preserved Ejection Fraction. J Nucl Med 58:781-783
Maxfield, Mark W; Stacy, Mitchel R; Kurobe, Hirotsugu et al. (2017) Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med 12:929-938
Feher, Attila; Sinusas, Albert J (2017) Assessment of right ventricular metabolism: An emerging tool for monitoring pulmonary artery hypertension. J Nucl Cardiol 24:1990-1993
Liu, Qingyi; Mohy-Ud-Din, Hassan; Boutagy, Nabil E et al. (2017) Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Phys Med Biol 62:3944-3957
Ferrandino, Giuseppe; Kaspari, Rachel R; Reyna-Neyra, Andrea et al. (2017) An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. Sci Rep 7:5329
Boutagy, Nabil E; Sinusas, Albert J (2017) Recent Advances and Clinical Applications of PET Cardiac Autonomic Nervous System Imaging. Curr Cardiol Rep 19:33

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