See instmctions): This is an application for a new Ruth L. Kirschstein Institutional National Research Service Award (T32), entitled Training Program in Cardiovascular Sciences. The program is designed to provide closely mentored, multidisciplinary postdoctoral research training to highly promising physician-scientists and PhDs and prepare them for careers as independent cardiovascular investigators. We embark upon this program to meet the needs of a growing pool of talented candidates who wish to prepare themselves for research- intensive careers that will ultimately improve cardiovascular health in the United States and the world. The environment for advanced cardiovascular training at NYU has dramatically strengthened during the past seven years. We have recruited highly meritorious faculty investigators pursuing fundamental studies of cardiovascular biology and disease. In parallel, we have attracted a number of outstanding new faculty members with robust clinical research programs investigating mechanisms and therapy of cardiovascular disease, as well as healthcare delivery and effectiveness, particularly among the underserved in partnership with the New York City Health and Hospitals Corporation. From this talented group we have assembled a training faculty of eleven primary mentors and thirteen associated mentors organized into three major clusters of particular strength: (1) Myocardial/lon Channel Biology and Disease;(2) Vascular Biology and Disease;and (3) Clinical Research. The proposed program, which has substantial institutional support, will fund four trainees each year, most entering the program after completing the clinical portion of our ACGME- approved cardiology fellowship. All trainees will complete a two-year training program that includes: (1) a core program of didactics that stresses research tools, career development and the interface between biomedical research and clinical care;(2) an intensive, multi-disciplinary research project;and (3) a personalized, team-based mentoring program. We are confident that graduates of our program will pursue independent investigative careers and enhance cardiovascular health in the US and elsewhere.

Public Health Relevance

Cardiovascular disease remains the major cause of death in the US. Improvements in the outlook for those at risk of cardiovascular disease will come from multiple strategies, including fundamental laboratory research, clinical investigation, and improvements in healthcare delivery and effectiveness. This program will provide training to a cadre of scientists who use these multiple strategies to improve cardiovascular health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL098129-05
Application #
8508285
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2009-09-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$202,824
Indirect Cost
$19,272
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Yu, Mikyung; Amengual, Jaume; Menon, Arjun et al. (2017) Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Adv Healthc Mater 6:
Heffron, Sean P; Rockman, Caron B; Adelman, Mark A et al. (2017) Greater Frequency of Fruit and Vegetable Consumption Is Associated With Lower Prevalence of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol 37:1234-1240
Rahman, Karishma; Vengrenyuk, Yuliya; Ramsey, Stephen A et al. (2017) Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression. J Clin Invest 127:2904-2915
Heffron, Sean P; Parikh, Amar; Volodarskiy, Alexandar et al. (2016) Changes in Lipid Profile of Obese Patients Following Contemporary Bariatric Surgery: A Meta-Analysis. Am J Med 129:952-9
Shah, Binita; Berger, Jeffrey S; Allen, Nicole et al. (2016) The assessment of thrombotic markers utilizing ionic versus non-ionic contrast during coronary angiography and intervention trial. Catheter Cardiovasc Interv 88:727-737
Ouimet, Mireille; Hennessy, Elizabeth J; van Solingen, Coen et al. (2016) miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Arterioscler Thromb Vasc Biol 36:942-951
Heffron, Sean P; Alviar, Carlos L; Towe, Christopher et al. (2016) Dyspnea and Chest Pain in a Young Woman Caused by a Giant Pericardial Lymphohemangioma: Diagnosis and Treatment. Can J Cardiol 32:1260.e23-1260.e25
Bradfield, Paul F; Menon, Arjun; Miljkovic-Licina, Marijana et al. (2016) Divergent JAM-C Expression Accelerates Monocyte-Derived Cell Exit from Atherosclerotic Plaques. PLoS One 11:e0159679
Balakrishnan, Revathi; Berger, Jeffrey S; Tully, Lisa et al. (2015) Prevalence of unrecognized diabetes, prediabetes and metabolic syndrome in patients undergoing elective percutaneous coronary intervention. Diabetes Metab Res Rev 31:603-9
Heffron, Sean P; Rockman, Caron B; Gianos, Eugenia et al. (2015) Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease. Prev Med 72:15-8

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