This is a new T32 application from the Division of Pediatric Cardiology of the Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt. Our long- term goal is to build upon the success of the Division in training academic pediatric cardiologists by developing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of pediatric cardiovascular disease after birth. In addition to trainees in the Pediatric Cardiology, clinical fellows in related Pediatric subspecialties such as Pulmonary Medicine, Critical Care Medicine, and Neonatology as well as Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will primarily be identified from the pool of applicants for pediatric cardiology fellowship (102 applicants for 2 positions in 2010). This proposal will fund the second and third years of fellowship, during which the trainee will carry out the mentored research. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. The Department and Division are committed to funding the first and fourth years of this training. The program directors will use an internal advisory committee, comprised of successful physician-scientists from within Vanderbilt, as well as an external advisory committee that includes experts in both clinical and basic research who are also program directors for current T32 applications in Pediatric Cardiology. Using the unique strengths of Vanderbilt University in the areas of developmental biology, vascular biology, regenerative medicine and tissue engineering, cardiovascular pharmacology and pharmacogenetics, and population as well as outcomes based research, the program will help train the next generation of physician scientists. By including former trainees as Mentors-in-training, the program will assist these junior faculty members in their academic careers as well as maintain a cadre of mentors for the future success of this program.

Public Health Relevance

DEVELOPMENTAL DETERMINANTS OF CARDIOVASCULAR DISEASE PROJECT NARRATIVE (Relevance) This proposal builds upon the past record of the Thomas P. Graham Division of Pediatric Cardiology at Vanderbilt in training academic pediatric cardiologists, and in particular, upon a successful pilot program integrating 2 years (to be funded in the future by this proposal) of mentored research training including an MSCI degree, with 2 years of clinical training (to be funded by the Division of Pediatric Cardiology and the Department of Pediatrics). With a theme of investigating developmental determinants of cardiovascular disease, this program will be essential in ensuring the continued success of training the next generation of physician-scientists who can carry out research in pediatric cardiovascular disease and apply this new knowledge to the care of children and young adults with congenital and acquired heart disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
1T32HL105334-01A1
Application #
8151922
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$450,985
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Mouledoux, J; Guerra, S; Ballweg, J et al. (2017) A novel, more efficient, staged approach for critical congenital heart disease screening. J Perinatol 37:288-290
McKane, Meghann; Soslow, Jonathan H; Xu, Meng et al. (2017) Does Body Mass Index Predict Premature Cardiomyopathy Onset for Duchenne Muscular Dystrophy? J Child Neurol 32:499-504
Nixon, Benjamin R; Williams, Alexandra F; Glennon, Michael S et al. (2017) Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development. JCI Insight 2:e90656
Wells, Quinn S; Veatch, Olivia J; Fessel, Joshua P et al. (2017) Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenet Genomics 27:247-254
Walker, Tracie C; Renno, Markus S; Parra, David A et al. (2016) Neonatal ventricular fibrillation and an elusive ALCAPA: things are not always as they seem. BMJ Case Rep 2016:
Hempel, Jonathan E; Hong, Charles C (2015) Practical strategies for small-molecule probe development in chemical biology. Methods Mol Biol 1263:209-23
Hempel, Jonathan E; Williams, Charles H; Hong, Charles C (2015) Preface. Chemical biology. Methods Mol Biol 1263:v
Feaster, Tromondae K; Cadar, Adrian G; Wang, Lili et al. (2015) Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res 117:995-1000
Williams, Charles H; Hempel, Jonathan E; Hao, Jijun et al. (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep 11:43-50
Shuplock, Jacqueline M; Smith, Andrew H; Owen, Jill et al. (2015) Association between perioperative dexmedetomidine and arrhythmias after surgery for congenital heart disease. Circ Arrhythm Electrophysiol 8:643-50

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