In this application for predoctoral training on """"""""Integrative Bioengineering of Heart, Vessels, and Blood"""""""", we propose to train outstanding Ph.D. candidates to carry out interdisciplinary research at the interface of engineering and biomedical sciences of heart, blood vessels and blood, with an emphasis on the use of integrative and systems approaches. The trainees will learn how to integrate engineering principles and technology and the vast amount of biomedical knowledge to generate systems-wide understanding from the genetic, molecular, cellular to the tissue-organ levels of the cardiovascular (CV) system in health and disease. This is a Multi-PD Training Grant application, with the leadership team composed of four PDs: Dr. Shu Chien will be the Contact PD, and the PDs for the three focus research areas are Drs. Andrew McCulloch (Heart), Geert Schmid-Schvnbein (Vessels), and Marcos Intaglietta (Blood). The training faculty includes outstanding scientists, engineers, and physicians at the UCSD Jacobs School of Engineering and School of Medicine, who have had a long history of collaborative research and training. A Training Grant Steering Committee (TGSC) will be responsible for the recruitment, admission, training, review, and support of the trainees. Special efforts will be made to recruit and admit underrepresented minorities and disabled and disadvantaged students. The Curriculum has core courses on CV Life Sciences and CV Biophysical Sciences and new courses specifically designed for this TG. The trainees will receive education on responsible conduct of research and ethics. The TGSC will organize seminars and journal clubs for the trainees, as well as holding regular meetings with the trainees. The PDs will coordinate the research training activities within each area, and they collaborate in formulating research training programs at the interfaces. The training program will be assessed periodically and enhanced by trainee surveys and reviews by Internal and External Advisory Committees.
The aim of this Training Grant is to train scientists who have the knowledge to use an integrative and systems approach in cardiovascular research for the development of new understanding in cardiovascular bioengineering, medicine, and healthcare, as well as new advances in translation and interventions.

Public Health Relevance

The research projects performed by the trainees have potential applications to cardiovascular diseases, including hypertension, atherosclerosis, diabetes, coronary heart disease, heart failure, cerebrovascular disease, shock, peripheral vascular disorders, and blood diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL105373-05
Application #
8722010
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2010-09-20
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Engineering (All Types)
Type
Schools of Arts and Sciences
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Yeh, Yi-Ting; Serrano, Ricardo; Fran├žois, Joshua et al. (2018) Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc Natl Acad Sci U S A 115:133-138
Getz, Michael C; Nirody, Jasmine A; Rangamani, Padmini (2018) Stability analysis in spatial modeling of cell signaling. Wiley Interdiscip Rev Syst Biol Med 10:
Ho, Gordon; Hoffmayer, Kurt S; Villongco, Christopher T et al. (2018) Successful ventricular fibrillation functional substrate ablation via a single vascular access site. HeartRhythm Case Rep 4:173-176
Gharibans, Armen A; Smarr, Benjamin L; Kunkel, David C et al. (2018) Artifact Rejection Methodology Enables Continuous, Noninvasive Measurement of Gastric Myoelectric Activity in Ambulatory Subjects. Sci Rep 8:5019
Lye, Theresa H; Vincent, Kevin P; McCulloch, Andrew D et al. (2018) Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography. Biophys J 114:1477-1489
Limsakul, Praopim; Peng, Qin; Wu, Yiqian et al. (2018) Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface. Cell Chem Biol 25:370-379.e4
Spang, Martin T; Christman, Karen L (2018) Extracellular matrix hydrogel therapies: In vivo applications and development. Acta Biomater 68:1-14
Pan, Yijia; Yoon, Sangpil; Sun, Jie et al. (2018) Mechanogenetics for the remote and noninvasive control of cancer immunotherapy. Proc Natl Acad Sci U S A 115:992-997
Sugie, Joseph; Intaglietta, Marcos; Sung, Lanping Amy (2018) Water transport and homeostasis as a major function of erythrocytes. Am J Physiol Heart Circ Physiol 314:H1098-H1107
Tang, Xia; Liu, Yanyan; Xiao, Qian et al. (2018) Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway. J Cell Biochem 119:8260-8270

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