In this application for predoctoral training on """"""""Integrative Bioengineering of Heart, Vessels, and Blood"""""""", we propose to train outstanding Ph.D. candidates to carry out interdisciplinary research at the interface of engineering and biomedical sciences of heart, blood vessels and blood, with an emphasis on the use of integrative and systems approaches. The trainees will learn how to integrate engineering principles and technology and the vast amount of biomedical knowledge to generate systems-wide understanding from the genetic, molecular, cellular to the tissue-organ levels of the cardiovascular (CV) system in health and disease. This is a Multi-PD Training Grant application, with the leadership team composed of four PDs: Dr. Shu Chien will be the Contact PD, and the PDs for the three focus research areas are Drs. Andrew McCulloch (Heart), Geert Schmid-Schvnbein (Vessels), and Marcos Intaglietta (Blood). The training faculty includes outstanding scientists, engineers, and physicians at the UCSD Jacobs School of Engineering and School of Medicine, who have had a long history of collaborative research and training. A Training Grant Steering Committee (TGSC) will be responsible for the recruitment, admission, training, review, and support of the trainees. Special efforts will be made to recruit and admit underrepresented minorities and disabled and disadvantaged students. The Curriculum has core courses on CV Life Sciences and CV Biophysical Sciences and new courses specifically designed for this TG. The trainees will receive education on responsible conduct of research and ethics. The TGSC will organize seminars and journal clubs for the trainees, as well as holding regular meetings with the trainees. The PDs will coordinate the research training activities within each area, and they collaborate in formulating research training programs at the interfaces. The training program will be assessed periodically and enhanced by trainee surveys and reviews by Internal and External Advisory Committees.
The aim of this Training Grant is to train scientists who have the knowledge to use an integrative and systems approach in cardiovascular research for the development of new understanding in cardiovascular bioengineering, medicine, and healthcare, as well as new advances in translation and interventions.

Public Health Relevance

The research projects performed by the trainees have potential applications to cardiovascular diseases, including hypertension, atherosclerosis, diabetes, coronary heart disease, heart failure, cerebrovascular disease, shock, peripheral vascular disorders, and blood diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL105373-05
Application #
8722010
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2010-09-20
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Engineering (All Types)
Type
Schools of Arts and Sciences
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sessions, Ayla O; Kaushik, Gaurav; Parker, Sarah et al. (2016) Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan. Matrix Biol :
Krishnamurthy, Adarsh; Gonzales, Matthew J; Sturgeon, Gregory et al. (2016) Biomechanics Simulations Using Cubic Hermite Meshes with Extraordinary Nodes for Isogeometric Cardiac Modeling. Comput Aided Geom Des 43:27-38
Aung, Aereas; Bhullar, Ivneet Singh; Theprungsirikul, Jomkuan et al. (2016) 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. Lab Chip 16:153-62
Kaushik, Gaurav; Spenlehauer, Alice; Sessions, Ayla O et al. (2015) Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med 7:292ra99
Mazor, Rafi; Schmid-Schönbein, Geert W (2015) Proteolytic receptor cleavage in the pathogenesis of blood rheology and co-morbidities in metabolic syndrome. Early forms of autodigestion. Biorheology 52:337-52
Vincent, Kevin P; Gonzales, Matthew J; Gillette, Andrew K et al. (2015) High-order finite element methods for cardiac monodomain simulations. Front Physiol 6:217
Davey, Shruti Krishna; Aung, Aereas; Agrawal, Gaurav et al. (2015) Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. Tissue Eng Part C Methods 21:1188-96
McArdle, Sara; Chodaczek, Grzegorz; Ray, Nilanjan et al. (2015) Intravital live cell triggered imaging system reveals monocyte patrolling and macrophage migration in atherosclerotic arteries. J Biomed Opt 20:26005
Viswanathan, Meera Cozhimuttam; Kaushik, Gaurav; Engler, Adam J et al. (2014) A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function. Circ Res 114:e6-17
Grover, Gregory N; Rao, Nikhil; Christman, Karen L (2014) Myocardial matrix-polyethylene glycol hybrid hydrogels for tissue engineering. Nanotechnology 25:014011

Showing the most recent 10 out of 22 publications