A decline in the number of physician scientists in the United States, correlates with the NIH Roadmap's concern about the lack of well-trained individuals with the capacity to translate research from bench to bedside. Cardiovascular diseases remain the leading cause of mortality and morbidity in the United States and the growth of the aged population over the next 20 years will dramatically increase the incidence of peripheral vascular disease and the need for new and improved treatment options for these diseases. Thus, great need exists for formal training programs to prepare future scientists, engineers, and clinicians who can advance the science behind therapies for vascular patients. This application proposes a multidisciplinary and collaborative training program that will co-train young physicians and scientists with interests in vascular biology. The overall goal of the proposed "Vascular Surgery Research Training Program" is to provide a comprehensive and hypothesis-based research experience to future investigators who are strongly motivated towards a career in vascular surgery and vascular research. The program will provide trainees with multiple opportunities for research activities in broad areas of vascular biology, drug development/delivery, vascular imaging and health services. The program will also foster the development of knowledge, competence, skills, professional attitudes, and experience required for successful academic careers in independent NIH-funded research. The specific objectives of this program are to: 1) through a two-year postdoctoral research training experience for selected surgical residents or medical residents/fellows, provide training in the conduct of basic, translational, health services research through participation in an individual and tailored didacti and mentoring program utilizing the extensive resources of the UW Department of Surgery, UW Cardiovascular Research Center, UW College of Engineering and UW School of Medicine and Public Health, including the Institute for Clinical and Translational Research (ICTR), 2) encourage recent doctoral graduates with a background in molecular biology, cell biology, physiology, chemical engineering, biomedical engineering, or other disciplines to pursue academic research careers in the field of vascular biology by providing two to three year postdoctoral training, 3) develop physician-scientists and leaders in academic surgery with an emphasis on vascular diseases and 4) expand the pool of surgeon-scientists with comprehensive training in health services research. The application includes a pool of experienced, extramurally funded trainers from a variety of vascular- related disciplines including surgery, radiology, population health, and biomedical engineering;and incorporates effective assessment processes, a plan to promote diversity by recruiting and retaining both women and minorities, and a comprehensive plan for training in the responsible conduct of research. The program directors have demonstrated success in a similar program at their previous institution and the University of Wisconsin offers an excellent environment for the continued success of the program.

Public Health Relevance

A decline in the number of physician scientists will impact our Nation's capacity to translate research from bench to bedside while vascular diseases becoming increasingly prominent. This formal training program will prepare future scientists, engineers, and clinicians to lead successful academic careers and research that will lead to new and improved therapies for vascular patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL110853-02
Application #
8463030
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
2012-05-01
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$253,293
Indirect Cost
$17,429
Name
University of Wisconsin Madison
Department
Surgery
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Liu, Zhenjie; Wang, Qiwei; Ren, Jun et al. (2015) Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta. J Vasc Surg 62:1607-1614.e2
Wang, Qiwei; Ren, Jun; Morgan, Stephanie et al. (2014) Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. PLoS One 9:e92053
Saunders, Richard Scott; Fernandes-Taylor, Sara; Rathouz, Paul J et al. (2014) Outpatient follow-up versus 30-day readmission among general and vascular surgery patients: a case for redesigning transitional care. Surgery 156:949-56
Shi, Xudong; DiRenzo, Daniel; Guo, Lian-Wang et al. (2014) TGF-?/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation. PLoS One 9:e93995
Shi, X; Guo, L-W; Seedial, S M et al. (2014) TGF-?/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A. Cell Death Dis 5:e1317
Guo, Lian-Wang; Wang, Bowen; Goel, Shakti A et al. (2014) Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries. Circ Cardiovasc Interv 7:594-601
Saunders, Richard S; Fernandes-Taylor, Sara; Kind, Amy J H et al. (2014) Rehospitalization to primary versus different facilities following abdominal aortic aneurysm repair. J Vasc Surg 59:1502-10, 1510.e1-2
Wiseman, Jason T; Guzman, Amanda M; Fernandes-Taylor, Sara et al. (2014) General and vascular surgery readmissions: a systematic review. J Am Coll Surg 219:552-69.e2
Seedial, Stephen M; Ghosh, Soumojit; Saunders, R Scott et al. (2013) Local drug delivery to prevent restenosis. J Vasc Surg 57:1403-14