This proposal requests support for continuation of T32 MH016804 (Years 31-35). This highly successful T32 has traditionally trained individuals in both purely clinical and in translational neuroscience research. In this renewal application we have enhanced the emphasis of T32 MH016804 on translational neuroscience research training, so as to prepare the next generation of researchers to make discoveries that increase the variety and specificity of interventions to treat and prevent mental illness. Accordingly, we have re-titled our application """"""""Training for Transformative Discovery in Psychiatry"""""""". Our plan to emphasize training in studies engaged in forward and backward """"""""T1"""""""" translational research derives from our model for discovery in psychiatry (Fig 1). To support this goal, our training program has been augmented to ensure that: 1) Clinically trained individuals develop """"""""fluency"""""""" in basic neuroscience knowledge;2) Individuals with prior basic neuroscience training will receive exposures designed to help them develop """"""""fluency"""""""" in the clinical, pathophysiologic, and pathologic manifestations of mental illness, and;3) All participants receive training in translational strategies and techniques. Ultimately, trainees should acquire the ability to critically evaluate hypotheses and conduct experiments with knowledge of the clinical expression of mental illness, the associated cellular and molecular pathologies, the expected pathophysiologic mechanisms leading to the phenotype, and the possibilities and limitations of experimental models. Additional training focuses on professional skill development, the conduct of interdisciplinary research, and the responsible conduct of research. To achieve these training goals we have identified a new Director, Robert A. Sweet, M.D., chosen for his experience as a senior translational neuroscience investigator and his record of outstanding mentorship of translational neuroscience investigators. Dr. Sweet will be supported by the former Director, Charles F. Reynolds, III, M.D., an acclaimed mentor of clinical investigators whose ongoing engagement as Co-Director will also ensure programmatic continuity. They will be joined by new Co-Director, Etienne Sibille, Ph.D., who brings the perspective of a basic neuroscientist to the conduct of translational neuroscience studies of mental illness. We have similarly enhanced the training faculty by including new members with strong funding and training records in translational neuroscience, and by the inclusion of promising earlier career investigators who, through a co-mentorship model will be given the opportunity to develop as mentors. Combining the strong track record in the successful training of psychiatry researchers and mentors established during the past 30 years of success of T32 MH016804 with the guidance and emphasis on new discovery derived from the highly successful Translational Neuroscience Program at the University of Pittsburgh is anticipated to invigorate the Research Training Program supported by this application and promote the development of the next generation of translational neuroscience researchers and research mentors.

Public Health Relevance

Training for Transformative Discovery in Psychiatry is an institutional training grant designed to educate physicians and Ph.D. level scientists in conducting research which utilizes the recent advances in our understanding of brain development and function to lead to discoveries of novel treatments for mental illness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH016804-33
Application #
8454489
Study Section
Special Emphasis Panel (ZMH1-ERB-S (01))
Program Officer
Chavez, Mark
Project Start
1981-08-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$199,649
Indirect Cost
$14,254
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
McKinney, Brandon C; Lin, Huang; Ding, Ying et al. (2018) DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia. Schizophr Res 196:39-44
Rincón-Cortés, Millie; Gagnon, Kimberly G; Dollish, Hannah K et al. (2018) Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine. Neuropsychopharmacology 43:2418-2425
Hildebrandt, Britny A; Sinclair, Elaine B; Sisk, Cheryl L et al. (2018) Exploring reward system responsivity in the nucleus accumbens across chronicity of binge eating in female rats. Int J Eat Disord 51:989-993
Krivinko, Josh M; Erickson, Susan L; Ding, Ying et al. (2018) Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease. Am J Psychiatry 175:999-1009
Russell, Theron A; Grubisha, Melanie J; Remmers, Christine L et al. (2018) A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability. Biol Psychiatry 83:499-508
Chang, Miao; Womer, Fay Y; Edmiston, E Kale et al. (2018) Neurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study. Schizophr Bull 44:65-74
Rincón-Cortés, Millie; Grace, Anthony A (2017) Sex-Dependent Effects of Stress on Immobility Behavior and VTA Dopamine Neuron Activity: Modulation by Ketamine. Int J Neuropsychopharmacol 20:823-832
Hafeman, Danella; Bebko, Genna; Bertocci, Michele A et al. (2017) Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders. J Affect Disord 208:94-100
McKinney, Brandon C; Lin, Huang; Ding, Ying et al. (2017) DNA methylation evidence against the accelerated aging hypothesis of schizophrenia. NPJ Schizophr 3:13
McKinney, B; Ding, Y; Lewis, D A et al. (2017) DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia. Transl Psychiatry 7:e1032

Showing the most recent 10 out of 115 publications