This is a request for continued support of a predoctoral training program in Behavioral and Cognitive Neuroscience at the University of Pennsylvania. The program is designed to prepare exceptional students for a productive research career in the neurobiological basis of behavior. Behavioral and cognitive neuroscientists at Penn use a variety of experimental approaches to study the neural substrates of learning, perception, cognition, language, stress, sleep, circadian rhythms and synaptic plasticity. Training at both the behavioral/cognitive and cellular/molecular levels is ensured by training faculty drawn from departments in three schools of the University of Pennsylvania. Graduate education in the Biomedical and Life Sciences is based on independent interdepartmental """"""""Graduate Groups"""""""" that foster multi-disciplinary training courses and laboratory rotations from a rich and varied menu. The separate, University-mandated Office of Biomedical Graduate Studies (BGS) ensures curricular development, quality control, and uniform admissions standards. Management of the training program will be by an interdepartmental executive committee that sets and reviews policy and selects and evaluates the progress of trainees. The proposed training program serves as the major source of support for students interested in behavioral and cognitive neuroscience for five Graduate Groups (Neuroscience, Psychology, Pharmacology, Cellular and Molecular Biology, and Biology). Predoctoral trainees can participate in interdisciplinary and collaborative research in the areas of motivated behaviors, affect and stress, animal models of endophenotypes of psychiatric disorders, neural plasticity, learning and memory or cognitive neuroscience. The training program encourages broad training with a behavioral and cognitive emphasis by offering cooperatively taught courses, a biweekly Behavioral and Cognitive Neuroscience Seminar Series and associated journal club, monthly research discussions and an annual Behavioral and Cognitive Neuroscience Retreat. In view of the continued expansion of Behavioral and Cognitive Neuroscience faculty at Penn, and the number of highly qualified trainees, we are requesting support for seven trainees per year for the next five years. Psychiatric disorders, including depression, bipolar disorder and schizophrenia are debilitating conditions, and an estimated one in four adults suffers from a diagnosable mental disorder in a given year. This proposal seeks funds to train predoctoral students in the fields of behavioral and cognitive neuroscience - areas of research that seek to understand the fundamental mechanisms underlying behavior and the behavioral alterations observed is patients with psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH017168-30
Application #
8494080
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Rosemond, Erica K
Project Start
1984-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
30
Fiscal Year
2013
Total Cost
$225,053
Indirect Cost
$10,793
Name
University of Pennsylvania
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Choi, Kyuhyun; Holly, Elizabeth N; Davatolhagh, M Felicia et al. (2018) Integrated anatomical and physiological mapping of striatal afferent projections. Eur J Neurosci :
Grissom, N M; McKee, S E; Schoch, H et al. (2018) Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders. Mol Psychiatry 23:544-555
Murphy, Andrew C; Muldoon, Sarah F; Baker, David et al. (2018) Structure, function, and control of the human musculoskeletal network. PLoS Biol 16:e2002811
Reddy, Pranav G; Mattar, Marcelo G; Murphy, Andrew C et al. (2018) Brain state flexibility accompanies motor-skill acquisition. Neuroimage 171:135-147
Doshi, Shachee; Gupta, Preetika; Kalb, Robert G (2017) Genetic induction of hypometabolism by ablation of MC4R does not suppress ALS-like phenotypes in the G93A mutant SOD1 mouse model. Sci Rep 7:13150
Wood, Katherine C; Blackwell, Jennifer M; Geffen, Maria Neimark (2017) Cortical inhibitory interneurons control sensory processing. Curr Opin Neurobiol 46:200-207
Tang, Sheng; Wang, I-Ting Judy; Yue, Cuiyong et al. (2017) Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice. J Neurosci 37:7420-7437
Merkow, Maxwell B; Burke, John F; Ramayya, Ashwin G et al. (2017) Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting. Brain Stimul 10:645-650
Schoch, Hannah; Kreibich, Arati S; Ferri, Sarah L et al. (2017) Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene. Biol Psychiatry 81:193-202
Dubowy, Christine; Sehgal, Amita (2017) Circadian Rhythms and Sleep in Drosophila melanogaster. Genetics 205:1373-1397

Showing the most recent 10 out of 80 publications