This is a request for continued support of a predoctoral training program in Behavioral and Cognitive Neuroscience at the University of Pennsylvania. The program is designed to prepare exceptional students for a productive research career in the neurobiological basis of behavior. Behavioral and cognitive neuroscientists at Penn use a variety of experimental approaches to study the neural substrates of learning, perception, cognition, language, stress, sleep, circadian rhythms and synaptic plasticity. Training at both the behavioral/cognitive and cellular/molecular levels is ensured by training faculty drawn from departments in three schools of the University of Pennsylvania. Graduate education in the Biomedical and Life Sciences is based on independent interdepartmental "Graduate Groups" that foster multi-disciplinary training courses and laboratory rotations from a rich and varied menu. The separate, University-mandated Office of Biomedical Graduate Studies (BGS) ensures curricular development, quality control, and uniform admissions standards. Management of the training program will be by an interdepartmental executive committee that sets and reviews policy and selects and evaluates the progress of trainees. The proposed training program serves as the major source of support for students interested in behavioral and cognitive neuroscience for five Graduate Groups (Neuroscience, Psychology, Pharmacology, Cellular and Molecular Biology, and Biology). Predoctoral trainees can participate in interdisciplinary and collaborative research in the areas of motivated behaviors, affect and stress, animal models of endophenotypes of psychiatric disorders, neural plasticity, learning and memory or cognitive neuroscience. The training program encourages broad training with a behavioral and cognitive emphasis by offering cooperatively taught courses, a biweekly Behavioral and Cognitive Neuroscience Seminar Series and associated journal club, monthly research discussions and an annual Behavioral and Cognitive Neuroscience Retreat. In view of the continued expansion of Behavioral and Cognitive Neuroscience faculty at Penn, and the number of highly qualified trainees, we are requesting support for seven trainees per year for the next five years. Psychiatric disorders, including depression, bipolar disorder and schizophrenia are debilitating conditions, and an estimated one in four adults suffers from a diagnosable mental disorder in a given year. This proposal seeks funds to train predoctoral students in the fields of behavioral and cognitive neuroscience - areas of research that seek to understand the fundamental mechanisms underlying behavior and the behavioral alterations observed is patients with psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH017168-30
Application #
8494080
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Rosemond, Erica K
Project Start
1984-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
30
Fiscal Year
2013
Total Cost
$225,053
Indirect Cost
$10,793
Name
University of Pennsylvania
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mattar, Marcelo G; Kahn, David A; Thompson-Schill, Sharon L et al. (2016) Varying Timescales of Stimulus Integration Unite Neural Adaptation and Prototype Formation. Curr Biol 26:1669-76
Greenberg, Jeffrey A; Burke, John F; Haque, Rafi et al. (2015) Decreases in theta and increases in high frequency activity underlie associative memory encoding. Neuroimage 114:257-63
Natan, Ryan G; Briguglio, John J; Mwilambwe-Tshilobo, Laetitia et al. (2015) Complementary control of sensory adaptation by two types of cortical interneurons. Elife 4:
Haque, Rafi U; Wittig Jr, John H; Damera, Srikanth R et al. (2015) Cortical Low-Frequency Power and Progressive Phase Synchrony Precede Successful Memory Encoding. J Neurosci 35:13577-86
Burke, John F; Ramayya, Ashwin G; Kahana, Michael J (2015) Human intracranial high-frequency activity during memory processing: neural oscillations or stochastic volatility? Curr Opin Neurobiol 31:104-10
Young, Matthew B; Thomas, Steven A (2014) M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current. J Neurosci 34:1570-8
Burke, John F; Long, Nicole M; Zaghloul, Kareem A et al. (2014) Human intracranial high-frequency activity maps episodic memory formation in space and time. Neuroimage 85 Pt 2:834-43
Kumar, Manoj; Duda, Jeffery T; Hwang, Wei-Ting et al. (2014) High resolution magnetic resonance imaging for characterization of the neuroligin-3 knock-in mouse model associated with autism spectrum disorder. PLoS One 9:e109872
Gilaie-Dotan, Sharon; Tymula, Agnieszka; Cooper, Nicole et al. (2014) Neuroanatomy predicts individual risk attitudes. J Neurosci 34:12394-401
Yaffe, Robert B; Kerr, Matthew S D; Damera, Srikanth et al. (2014) Reinstatement of distributed cortical oscillations occurs with precise spatiotemporal dynamics during successful memory retrieval. Proc Natl Acad Sci U S A 111:18727-32

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