This is the fifth competing application of the T32 Weill-Cornell Research Fellowship Program in Geriatric Mood Disorders, which has been offering multidisciplinary training for 20 years. Conceptually, we view mood disorders as heterogeneous with etiological contributions from genetic factors, aging- and disease-related biological changes, disability, and psychosocial factors. Methodologically, we teach biological assessment techniques as well as longitudinal designs and clinically-driven interventions at the patient, the practice, and the community levels. This approach has led to translational studies in a population with great health and mental health needs. The Program's strengths are: 1) The academic record of its trainees;the 17 fellows trained of the past 10 years received 22 grants and coauthored 101 papers (41 first-authored);2) Leadership in research training at a national level (PIs of the NIMH Summer Research Institute and the Advanced Research Institute);3) NIMH- funded faculty in translational research ranging from molecular genetics, neuroimaging, clinical pharmacology, intervention development, and mental health services research;4) Cohesive organization of the Cornell ACISR;5) Five pilot project programs;6) Rich study populations and laboratory resources;7) Databases available for secondary analyses and hypothesis generation by the fellows;8) Long and effective collaboration with investigators of Geriatric Medicine, General Internal Medicine, Clinical Epidemiology and Services Research Program, Public Health and Medical Ethics;and 9) Leadership in 8 multisite studies. The Program will be directed by funded investigators in clinical biology (G. Alexopoulos) and health services research (M. Bruce) with a strong record in research training and by an Executive Committee with expertise in molecular genetics, neuroimaging, and treatment development. We request support for 2 trainees per year, whose individualized training programs will be coordinated by two preceptors (e.g. one clinical and one basic investigator or one services and one clinical investigator) to facilitate translation research. Beyond a Core Curriculum, we guide and support our trainees in conducting their own research studies, in preparing competitive funding applications, and in publishing data-based papers.

Public Health Relevance

This Research Fellowship has successfully trained many generations of physicians and Ph.D. scientists and prepared them for a research career in geriatric mood disorders over 20 years. We propose to continue doing so for another five years as we believe that our future capacity to reduce the burden of late-life mood disorders rests on the development of tomorrow's scientific leaders. To that end, the Fellowship will use proven and innovative strategies to promote the growth of new generations of investigators committed to translational, interventions, and services research on late-life mental health and illness.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZMH1-ERB-I (01))
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Chavez, Mark
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Victoria, Lindsay W; Gunning, Faith M; Bress, Jennifer N et al. (2018) Reward learning impairment and avoidance and rumination responses at the end of Engage therapy of late-life depression. Int J Geriatr Psychiatry 33:948-955
Kim, Min-Hyung; Banerjee, Samprit; Zhao, Yize et al. (2018) Association networks in a matched case-control design - Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls. J Biomed Inform 87:88-95
Alexopoulos, George S; Sirey, Jo Anne; Banerjee, Samprit et al. (2018) Two Interventions for Patients with Major Depression and Severe Chronic Obstructive Pulmonary Disease: Impact on Dyspnea-Related Disability. Am J Geriatr Psychiatry 26:162-171
Alexopoulos, George S; O'Neil, Robert; Banerjee, Samprit et al. (2017) ""Engage"" therapy: Prediction of change of late-life major depression. J Affect Disord 221:192-197
Yohannes, Abebaw Mengistu; Raue, Patrick J; Kanellopoulos, Dora et al. (2016) Predictors of All-Cause Mortality in Patients With Severe COPD and Major Depression Admitted to a Rehabilitation Hospital. Chest 149:467-473
Morimoto, Sarah Shizuko; Gunning, Faith M; Wexler, Bruce E et al. (2016) Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. Am J Geriatr Psychiatry 24:816-20
Alexopoulos, George S; Raue, Patrick J; McCulloch, Charles et al. (2016) Clinical Case Management versus Case Management with Problem-Solving Therapy in Low-Income, Disabled Elders with Major Depression: A Randomized Clinical Trial. Am J Geriatr Psychiatry 24:50-59
Gustavson, Kristen A; Alexopoulos, George S; Niu, Grace C et al. (2016) Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction. Am J Geriatr Psychiatry 24:11-17
Morimoto, Sarah Shizuko; Kanellopoulos, Dora; Manning, Kevin J et al. (2015) Diagnosis and treatment of depression and cognitive impairment in late life. Ann N Y Acad Sci 1345:36-46
Alexopoulos, G S; Manning, K; Kanellopoulos, D et al. (2015) Cognitive control, reward-related decision making and outcomes of late-life depression treated with an antidepressant. Psychol Med 45:3111-20

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