This is the sixth competing application of the T32 Research Fellowship Program in Geriatric Mood Disorders, which has been offering multidisciplinary training for 25 years. This successful T32 has undergone continuous transformation in response to scientific developments, IOM mandates, the 2015 NIMH Strategic Priorities, the RDoC Project, and the evolving expertise of our current faculty. The new T32 organizes its research training in a continuum in which our clinical neurobiology studies provide targets for our novel treatment development initiatives and our services research seeks to extend the quality and reach of mental health treatment in the community. The Program's strengths are: 1) The academic record of its trainees; the 13 fellows trained of the past 10 years received 17 grants and coauthored 94 papers (44 first-authored); 2) Leadership in research training at a national level (PIs of the NIMH Summer Research Institute and the NIMH Advanced Research Institute); 3) NIMH-funded faculty in translational research ranging from molecular genetics, neuroimaging, clinical pharmacology, intervention development, and mental health services research; 4) Cohesive organization of the Weill Cornell Institute of Geriatric Psychiatry; 5) Four Cornell pilot project programs; 6) Rich study populations and laboratory resources; 7) Databases available for secondary analyses and hypothesis generation by fellows; 8) Long and effective collaboration with investigators of Geriatric Medicine, General Internal Medicine, Clinical Epidemiology and Services Research Program, Public Health and Medical Ethics; and 9) Leadership in 9 multisite studies. The Program will be directed by funded investigators in clinical neurobiology (F. Gunning), novel treatment development (G. Alexopoulos) and services research (M. Bruce) with a strong record in research training and by an Executive Committee with expertise in molecular genetics, neuroimaging, treatment development, ethics, and minority studies. We request support for 3 trainee slots, whose personalized training programs will be coordinated by two mentors (e.g. one clinical and one basic investigator) to facilitate translation research. Beyond a Core Curriculum, we support our trainees in conducting their own studies, in preparing applications for competitive funding, and in publishing data-based papers.

Public Health Relevance

This Research Fellowship has prepared many generations of physicians and Ph.D. scientists for a successful research career in geriatric mood disorders over 25 years. We have transformed our training in response to changes in science, the IOM mandates, the 2015 NIMH Strategic Plan, the RDoC Project, and the evolution of our research team. We request to extend the fellowship for another 5 years as we believe that our future ability to reduce the burden of late-life mood disorders rests on the development of tomorrow's science leaders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019132-29
Application #
9660582
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Chavez, Mark
Project Start
1990-03-01
Project End
2021-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
29
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Victoria, Lindsay W; Gunning, Faith M; Bress, Jennifer N et al. (2018) Reward learning impairment and avoidance and rumination responses at the end of Engage therapy of late-life depression. Int J Geriatr Psychiatry 33:948-955
Kim, Min-Hyung; Banerjee, Samprit; Zhao, Yize et al. (2018) Association networks in a matched case-control design - Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls. J Biomed Inform 87:88-95
Alexopoulos, George S; Sirey, Jo Anne; Banerjee, Samprit et al. (2018) Two Interventions for Patients with Major Depression and Severe Chronic Obstructive Pulmonary Disease: Impact on Dyspnea-Related Disability. Am J Geriatr Psychiatry 26:162-171
Alexopoulos, George S; O'Neil, Robert; Banerjee, Samprit et al. (2017) ""Engage"" therapy: Prediction of change of late-life major depression. J Affect Disord 221:192-197
Yohannes, Abebaw Mengistu; Raue, Patrick J; Kanellopoulos, Dora et al. (2016) Predictors of All-Cause Mortality in Patients With Severe COPD and Major Depression Admitted to a Rehabilitation Hospital. Chest 149:467-473
Morimoto, Sarah Shizuko; Gunning, Faith M; Wexler, Bruce E et al. (2016) Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. Am J Geriatr Psychiatry 24:816-20
Alexopoulos, George S; Raue, Patrick J; McCulloch, Charles et al. (2016) Clinical Case Management versus Case Management with Problem-Solving Therapy in Low-Income, Disabled Elders with Major Depression: A Randomized Clinical Trial. Am J Geriatr Psychiatry 24:50-59
Gustavson, Kristen A; Alexopoulos, George S; Niu, Grace C et al. (2016) Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction. Am J Geriatr Psychiatry 24:11-17
Morimoto, Sarah Shizuko; Kanellopoulos, Dora; Manning, Kevin J et al. (2015) Diagnosis and treatment of depression and cognitive impairment in late life. Ann N Y Acad Sci 1345:36-46
Alexopoulos, G S; Manning, K; Kanellopoulos, D et al. (2015) Cognitive control, reward-related decision making and outcomes of late-life depression treated with an antidepressant. Psychol Med 45:3111-20

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