UCLA Post-Graduate Training Program in Psychoneuroimmunology (PNI) and Mental Health The University of California, Los Angeles, Post-Graduate Training Program in Psychoneuroimmunology (PNI) and Mental Health serves as a major campus facilitator for bridging training in the fields of behavioral science, neuroscience, and immunology, and is the sole comprehensive campus training program integrating concerns of basic and clinical immunologists with those of a wide range of neuroscientists and behavioral investigators. PNI is a scientific field that investigates bi-directional interactions among the neural, endocrine, and immune systems, and that studies inflammatory biology dynamics in behavior, with implications for mental health. Given its broad faculty resources, the training program familiarizes trainees with the diversity of information that is necessary for creative problem solving in basic and clinical PNI research, and provides a supportive yet critical research training environment with one-on-one supervision of research fellows. These training opportunities coupled with scientific review of fellows'research progress optimize the ability of trainees to achieve discrete training goals, project new experiments, and develop into competent and highly imaginative scientists with independent academic careers. Indeed, this training grant has taken optimal advantage of an active PNI faculty over the last 20 years and produced multiple outstanding PNI researchers such as Michael Irwin, Margaret Kemeny, Gayle Page, Steve Cole, and Julie Bower. Our goal in this training grant is to continue the multi-disciplinary education and training of 3 post- doctoral students from various backgrounds, chosen by virtue of their past records in creative and innovative research. Fellows are to work on their own projects under the mentorship of selected faculty who have a proven record of PNI research excellence. Our approach is to integrate clinical understanding along with state-of-the-art behavioral, neurobiological, and molecular neuroimmunological techniques. By combining a high level of methodological sophistication about clinically relevant issues and mechanisms with a firm grounding in behavior, neuroscience and immunology, we believe that the scientific knowledge base of PNI will be markedly advanced;such critical strategies engage trainees in the process of discovery of immune mechanisms that might underlie mental health disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH019925-15
Application #
8290519
Study Section
Special Emphasis Panel (ZMH1-ERB-Z (02))
Program Officer
Desmond, Nancy L
Project Start
1997-07-25
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2012
Total Cost
$152,352
Indirect Cost
$12,576
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Carroll, Judith E; Esquivel, Stephanie; Goldberg, Alyssa et al. (2016) Insomnia and Telomere Length in Older Adults. Sleep 39:559-64
Carroll, Judith E; Cole, Steven W; Seeman, Teresa E et al. (2016) Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun 51:223-9
Carroll, Judith E; Carrillo, Carmen; Olmstead, Richard et al. (2015) Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging. Sleep 38:205-11
Irwin, Michael R; Witarama, Tuff; Caudill, Marissa et al. (2015) Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans. Brain Behav Immun 47:86-92
Black, David S; O'Reilly, Gillian A; Olmstead, Richard et al. (2015) Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med 175:494-501
Carroll, Judith E; Irwin, Michael R; Stein Merkin, Sharon et al. (2015) Sleep and multisystem biological risk: a population-based study. PLoS One 10:e0118467
Cho, Hyong Jin; Seeman, Teresa E; Kiefe, Catarina I et al. (2015) Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun 46:319-26
Black, David S; O'Reilly, Gillian A; Olmstead, Richard et al. (2014) Mindfulness-based intervention for prodromal sleep disturbances in older adults: design and methodology of a randomized controlled trial. Contemp Clin Trials 39:22-7
Black, David S; Irwin, Michael R; Olmstead, Richard et al. (2014) Tai chi meditation effects on nuclear factor-κB signaling in lonely older adults: a randomized controlled trial. Psychother Psychosom 83:315-7
Himelstein, Sam; Saul, Stephen; Garcia-Romeu, Alberto et al. (2014) Mindfulness training as an intervention for substance user incarcerated adolescents: a pilot grounded theory study. Subst Use Misuse 49:560-70

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