This is a resubmission of the first competitive renewal of a T32 training grant at the Maryland Psychiatric Research Center (MPRC), originally funded in 2003 (MH067533). The goal of the proposed program is to prepare MDs, PhDs and PharmDs interested in basic or clinical research for a career in translational research in schizophrenia. The MPRC, a division of the University Of Maryland Medical School Department Of Psychiatry, is a focused center for schizophrenia research, located on the grounds of the Spring Grove Hospital Center, an inpatient mental health hospital located just outside Baltimore. The faculty of the MPRC have an integrated research program of clinical and neuroscience research into the neurophysiology, developmental origins, familial associations, symptoms, neurocognition, and treatment of schizophrenia. This successful research program is characterized by frequent interaction and collaboration among different preclinical and clinical researchers within the MPRC and nearby SOM campus. Postdoctoral training offered under this T32 fellowship has a primary focus on either basic neuroscience or clinical investigations of schizophrenia. All trainees are educated on the translational perspective of the MPRC and provided mentors and didactic training in both clinical and neuroscience in schizophrenia. This resubmission for a competitive five-year renewal application proposes to fund 3 new trainee positions in each year, with each a fellowship lasting for 2 years. Although this is a very young T32 program, it is successful in terms of recruiting and training independent researchers. During the initial funding period, 10 trainees were enrolled. Four trainees completed the training program, 1 withdrew for personal reasons and 5 are currently in training. Of the 4 that completed, 3 have faculty appointments at the Assistant Professor level (at the University of Maryland Baltimore, University of Wales, Bangor, and the University of Osnabruck) and one is currently employed at the MPRC as research associate. Three of these graduates have received competitive funding. One current trainee will graduate from this program in July and has secured an assistant professorship position at the University of Maryland Baltimore. In addition, 2 of the 5 current trainees have received competitive NARSAD Young Investigator awards.

Public Health Relevance

Complex problems such as schizophrenia require a multidisciplinary clinical research workforce, accustomed to working in integrated teams. This proposal seeks to address the dwindling number of translational scientists studying severe mental illness by recruiting and mentoring clinical and preclinical post-docs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH067533-10
Application #
8669163
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Chavez, Mark
Project Start
2004-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
$295,798
Indirect Cost
$22,025
Name
University of Maryland Baltimore
Department
Psychiatry
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Keller, William R; Fischer, Bernard A; McMahon, Robert et al. (2014) Community adherence to schizophrenia treatment and safety monitoring guidelines. J Nerv Ment Dis 202:6-12
Wright, Susan N; Kochunov, Peter; Chiappelli, Joshua et al. (2014) Accelerated white matter aging in schizophrenia: role of white matter blood perfusion. Neurobiol Aging 35:2411-8
Acheson, Ashley; Wijtenburg, S Andrea; Rowland, Laura M et al. (2014) Assessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders. Hum Brain Mapp 35:5401-13
Koola, Maju M; Tsapakis, Evangelia M; Wright, Padraig et al. (2014) Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites? J Psychopharmacol 28:665-670
Keller, William R; Vidal, Carol; Park, Eric S et al. (2014) The risk of diabetes in deficit schizophrenia. Clin Schizophr Relat Psychoses 7:235-7
Chiappelli, Joshua; Nugent, Katie L; Thangavelu, Kavita et al. (2014) Assessment of trait and state aspects of depression in schizophrenia. Schizophr Bull 40:132-42
Varghese, Sajoy P; Koola, Maju Mathew; Eiger, Rodney I et al. (2014) Opioid use remits, depression remains. Curr Psychiatr 13:45-50
Wilson, Christina A; Koenig, James I (2014) Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia. Eur Neuropsychopharmacol 24:759-73
Krause, Benjamin W; Wijtenburg, S Andrea; Holcomb, Henry H et al. (2014) Anterior cingulate GABA levels predict whole-brain cerebral blood flow. Neurosci Lett 561:188-91
Du, Xiaoming; Summerfelt, Ann; Chiappelli, Joshua et al. (2014) Individualized brain inhibition and excitation profile in response to paired-pulse TMS. J Mot Behav 46:39-48

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