In the wake of the successes in molecular biology, revealing information packed in the genome, behavioral scientists face the daunting task of integrating molecular events into the context of the whole organism, a challenge intensified by growing awareness that the behavior of one individual is exquisitely sensitive to the behaviors of others. Thus to understand the chain of events by which molecular events affect behavior we must not only place those events in the context of a single individual,but also in the context ofindividuals interacting with one another. Including this social sphere into our understanding will be crucial if we are ever to understand human behavioral disorders, since the most common of these (depression, schizophrenia, drug abuse) are very sensitive to the social environment. We propose interdisciplinary training of investigators to consider behavior from multiple levels of analysis, from molecular and cellular events to behavioral outcomes in a social context. Because social interactions can be tremendously complex, we must select models in both traditional and non-traditional species to take advantage of those specific influences of one individualupon the brain and behavior of another. As examples, we study: social learning of song in zebra finches;maternal stimulation of neonates in rats, mice, and voles;dominance hierarchies in spotted hyenas;social modulation of puberty in rats, Syrian hamsters and Siberian hamsters;as well as mating behaviors in a variety of vertebrates. Most of these models also reflect the influence of hormones upon neural structure and behavior because hormones mediate many social signals, and because hormones affect myriad targets in the body, including the brain, to coordinate social behavior. These hormone-sensitive systems permit us to study molecular events, too: secretion of specific hormones, activation of hormone receptor proteins, hormonal modulation of gene expression in the nervous system, nuclear co-factor proteins regulating hormone responsiveness, environmental contaminants altering reproductive behavior, brain peptides regulating parental behaviors, among others. This integration of information, from molecular to social events and back again, must be accomplished for any satisfying understandingof behavior. We have assembled a unique program to train the next generation of researchers to tackle the challenge of studying the contextual determinants of behavior.

Public Health Relevance

We will train graduate students and postdoctoral fellows in the organismal biology of social processes, which are crucial to human health. By exploring hormonal and genetic influences on social behaviors in humans and other species, we hope to gain a better understanding of disorders such as autism, ADHD, anorexia and schizophrenia, as well as societal issues such as aggression and parental behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH070343-10
Application #
8502759
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Desmond, Nancy L
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$121,676
Indirect Cost
$8,206
Name
Michigan State University
Department
None
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Hildebrandt, Britny A; Racine, Sarah E; Keel, Pamela K et al. (2015) The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. Int J Eat Disord 48:477-86
Bell, Margaret R; Meerts, Sarah H; Sisk, Cheryl L (2013) Adolescent brain maturation is necessary for adult-typical mesocorticolimbic responses to a rewarding social cue. Dev Neurobiol 73:856-69
Holekamp, Kay E; Swanson, Eli M; Van Meter, Page E (2013) Developmental constraints on behavioural flexibility. Philos Trans R Soc Lond B Biol Sci 368:20120350
Mohr, Margaret A; Sisk, Cheryl L (2013) Pubertally born neurons and glia are functionally integrated into limbic and hypothalamic circuits of the male Syrian hamster. Proc Natl Acad Sci U S A 110:4792-7
Munn-Chernoff, Melissa A; von Ranson, Kristin M; Culbert, Kristen M et al. (2013) An examination of the representativeness assumption for twin studies of eating pathology and internalizing symptoms. Behav Genet 43:427-35
Bell, Margaret R; De Lorme, Kayla C; Figueira, Rayson J et al. (2013) Adolescent gain in positive valence of a socially relevant stimulus: engagement of the mesocorticolimbic reward circuitry. Eur J Neurosci 37:457-68
Bell, Margaret R; Sisk, Cheryl L (2013) Dopamine mediates testosterone-induced social reward in male Syrian hamsters. Endocrinology 154:1225-34
Culbert, Kristen M; Breedlove, S Marc; Sisk, Cheryl L et al. (2013) The emergence of sex differences in risk for disordered eating attitudes during puberty: a role for prenatal testosterone exposure. J Abnorm Psychol 122:420-32
Kemp, Michael Q; Poort, Jessica L; Baqri, Rehan M et al. (2011) Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action. Hum Mol Genet 20:4475-90
Cohen, R E; Wade, J (2011) Aromatase mRNA in the brain of adult green anole lizards: effects of sex and season. J Neuroendocrinol 23:254-60

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