In the wake of the successes in molecular biology, revealing information packed in the genome, behavioral scientists face the daunting task of integrating molecular events into the context of the whole organism, a challenge intensified by growing awareness that the behavior of one individual is exquisitely sensitive to the behaviors of others. Thus to understand the chain of events by which molecular events affect behavior we must not only place those events in the context of a single individual,but also in the context ofindividuals interacting with one another. Including this social sphere into our understanding will be crucial if we are ever to understand human behavioral disorders, since the most common of these (depression, schizophrenia, drug abuse) are very sensitive to the social environment. We propose interdisciplinary training of investigators to consider behavior from multiple levels of analysis, from molecular and cellular events to behavioral outcomes in a social context. Because social interactions can be tremendously complex, we must select models in both traditional and non-traditional species to take advantage of those specific influences of one individualupon the brain and behavior of another. As examples, we study: social learning of song in zebra finches;maternal stimulation of neonates in rats, mice, and voles;dominance hierarchies in spotted hyenas;social modulation of puberty in rats, Syrian hamsters and Siberian hamsters;as well as mating behaviors in a variety of vertebrates. Most of these models also reflect the influence of hormones upon neural structure and behavior because hormones mediate many social signals, and because hormones affect myriad targets in the body, including the brain, to coordinate social behavior. These hormone-sensitive systems permit us to study molecular events, too: secretion of specific hormones, activation of hormone receptor proteins, hormonal modulation of gene expression in the nervous system, nuclear co-factor proteins regulating hormone responsiveness, environmental contaminants altering reproductive behavior, brain peptides regulating parental behaviors, among others. This integration of information, from molecular to social events and back again, must be accomplished for any satisfying understandingof behavior. We have assembled a unique program to train the next generation of researchers to tackle the challenge of studying the contextual determinants of behavior.

Public Health Relevance

We will train graduate students and postdoctoral fellows in the organismal biology of social processes, which are crucial to human health. By exploring hormonal and genetic influences on social behaviors in humans and other species, we hope to gain a better understanding of disorders such as autism, ADHD, anorexia and schizophrenia, as well as societal issues such as aggression and parental behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH070343-10
Application #
8502759
Study Section
Special Emphasis Panel (ZMH1-ERB-C (01))
Program Officer
Desmond, Nancy L
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$121,676
Indirect Cost
$8,206
Name
Michigan State University
Department
None
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Shuboni, Dorela D; Agha, Amna A; Groves, Thomas K H et al. (2016) The contribution of the pineal gland on daily rhythms and masking in diurnal grass rats, Arvicanthis niloticus. Behav Processes 128:1-8
Puts, David A; Hill, Alexander K; Bailey, Drew H et al. (2016) Sexual selection on male vocal fundamental frequency in humans and other anthropoids. Proc Biol Sci 283:
Hildebrandt, Britny A; Racine, Sarah E; Keel, Pamela K et al. (2015) The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. Int J Eat Disord 48:477-86
Shuboni, Dorela D; Cramm, Shannon L; Yan, Lily et al. (2015) Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus. Physiol Behav 138:75-86
Puts, David A; Pope, Lauramarie E; Hill, Alexander K et al. (2015) Fulfilling desire: evidence for negative feedback between men's testosterone, sociosexual psychology, and sexual partner number. Horm Behav 70:14-21
Culbert, Kristen M; Breedlove, S Marc; Sisk, Cheryl L et al. (2015) Age differences in prenatal testosterone's protective effects on disordered eating symptoms: developmental windows of expression? Behav Neurosci 129:18-36
Culbert, K M; Burt, S A; Sisk, C L et al. (2014) The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males. Psychol Med 44:2271-86
Bell, Margaret R; De Lorme, Kayla C; Figueira, Rayson J et al. (2013) Adolescent gain in positive valence of a socially relevant stimulus: engagement of the mesocorticolimbic reward circuitry. Eur J Neurosci 37:457-68
Holekamp, Kay E; Swanson, Eli M; Van Meter, Page E (2013) Developmental constraints on behavioural flexibility. Philos Trans R Soc Lond B Biol Sci 368:20120350
De Lorme, Kayla C; Sisk, Cheryl L (2013) Pubertal testosterone programs context-appropriate agonistic behavior and associated neural activation patterns in male Syrian hamsters. Physiol Behav 112-113:1-7

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