This Basic Science Training Program in the Neurobiology of Mental Illness (NMI) at UT Southwestern is designed to provide interdisciplinary, basic disease-oriented research training directly relevant to mental illness to predoctoral, postdoctoral and short-term summer fellows. This application for a new NMI Training Program at UT Southwestern is a direct response to NIMH's call for more basic scientists trained in a broad range of diverse, innovative basic research that closely informs our understanding and treatment of mental illness. In addition to the paucity of basic science researchers nationwide exploring the neurobiology of neuropsychiatric diseases, there is, conversely, a dearth of clinically-trained individuals pursuing basic research in mental illness, thus diminishing the very cross talk that is urgently needed in this field. The complexity of mental disorders demands an interdisciplinary approach to illuminate underlying disease mechanisms and to develop better diagnostic measures, treatments, and ultimately cures. Our NMI training program has numerous strengths, including: a) the outstanding environment at UT Southwestern in which to conduct basic, interdisciplinary biomedical research;b) the intellectual intensity and close-knit nature of the UT Southwestern neuroscience community;c) the integration of fundamental neurobiological research performed in multiple academic divisions;d) the unusually strong foundation at UT Southwestern to explore fundamental underpinnings of depression, schizophrenia and autism;e) the preexisting integration of basic science with clinical programs in mental illness;f) the breadth and depth of our potential trainees;g) calculated interactions between junior and senior mentors, thus ensuring that junior mentors will also benefit from the Training Program and will remain in mental health research in future years;and h) novel, translationally-oriented training components, such as hands-on neurophysiology and human neuroanatomy laboratories, a new Clinical Correlations Seminar, and the presence of a clinician on each trainee's doctoral thesis committee. The NMI Training Program is designed to encourage the best basic scientists-in-training to turn their attention to studying mental illness, with a purposeful endpoint being the development of new treatments for depression, schizophrenia, autism and developmental disorders, and other severe, common mental illnesses. The mental health research that is ongoing in the Department of Psychiatry has already inspired many UT Southwestern researchers to pursue mental health research. This Training Plan's goal of attracting and inspiring additional young scientists to pursue mental health research is both warranted and feasible given the truly exceptional and translational nature of the researchers, environment, and trainees offered by UT Southwestern.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-Y (02))
Program Officer
Chavez, Mark
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
Zip Code
Yun, Sanghee; Donovan, Michael H; Ross, Michele N et al. (2016) Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice. PLoS One 11:e0147256
Araujo, Daniel J; Anderson, Ashley G; Berto, Stefano et al. (2015) FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev 29:2081-96
Petrik, David; Latchney, Sarah E; Masiulis, Irene et al. (2015) Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells. Stem Cells 33:3655-65
Loerwald, Kristofer W; Patel, Ankur B; Huber, Kimberly M et al. (2015) Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during development. J Neurophysiol 113:786-95
Liang, Chang-Lin; Quang Nguyen, Tin; Marks, Gerald A (2014) Inhibitory and excitatory amino acid neurotransmitters are utilized by the projection from the dorsal deep mesencephalic nucleus to the sublaterodorsal nucleus REM sleep induction zone. Brain Res 1567:1-12
Wilkerson, Julia R; Tsai, Nien-Pei; Maksimova, Marina A et al. (2014) A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Rep 7:1589-600
Schaukowitch, Katie; Joo, Jae-Yeol; Liu, Xihui et al. (2014) Enhancer RNA facilitates NELF release from immediate early genes. Mol Cell 56:29-42
Schaukowitch, K; Kim, T-K (2014) Emerging epigenetic mechanisms of long non-coding RNAs. Neuroscience 264:25-38
Nguyen, Tin Quang; Liang, Chang-Lin; Marks, Gerald A (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. Brain Res 1527:131-40
Kumar, Jaswinder; Chuang, Jen-Chieh; Na, Elisa S et al. (2013) Differential effects of chronic social stress and fluoxetine on meal patterns in mice. Appetite 64:81-8

Showing the most recent 10 out of 19 publications