The proposed Neuroscience Training Program will offer prospective predoctoral students an exciting curriculum taught by a nationally and internationally recognized faculty, and a laboratory experience that builds on expertise in translational neuroscience, basic neurobiology, psychiatry and neurology, all uniquely 'interfaced'with one another due to close apposition of clinical and basic neuroscience research at the Mount Sinai Hospital and Mount Sinai School of Medicine. At the heart of the Training Program is Mount Sinai's Neuroscience Ph.D., the school's second Ph.D. granting program (Biomedical Sciences being the first), that was endorsed by the NYU Graduate School and approved by NY State in 2007. Participatingtrainingfaculty share a common thematic interest: study of the function and plasticity of specific neural circuits,during development, in the adult, and in the aged, diseased or degenerating nervous system. Varied laboratory opportunities at Mount Sinai School of Medicine take advantage of particular strengths in translational neuroscience, notably in developmental neurobiology, neural aging and degeneration, mechanisms of neuropsychiatric disease, cognitive neuroscience, computational neuroscience and neuroimaging, sensory signal transduction, neuroendocrinology and synaptic and behavioral plasticity. The nervous system is studied in diverse model systems, from 'simple'invertebrates such as the sea snail Aplysia, the fruit fly, or the worm C. elegans, all the way to complex vertebrates including nonhuman primates and humans. Students will receive a solid foundation in basic neurobiology, in a collaborative environment that actively promotes multidisciplinary, integrative research. Using this interdisciplinary approach, the Neuroscience Training Program will provide four students with the essential knowledge and experimental tools to initiate productive, independent careers in the laboratories of our training faculty.

Public Health Relevance

An estimated four million Americans suffer from Alzheimer's disease, other neurodegenerative conditions including Parkinson's disease, and neuropsychiatricdisease, which cumulatively represent an incredible public health burden. The proposed Neuroscience Training Program will educate talented young scientists, providing a firm foundation for productive, independent careers in neuroscience research and teaching.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
5T32MH087004-05
Application #
8488473
Study Section
Special Emphasis Panel (ZHD1-MRG-C (32))
Program Officer
Desmond, Nancy L
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$180,562
Indirect Cost
$8,634
Name
Icahn School of Medicine at Mount Sinai
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Golden, Sam A; Heshmati, Mitra; Flanigan, Meghan et al. (2016) Basal forebrain projections to the lateral habenula modulate aggression reward. Nature 534:688-92
Heshmati, Mitra; Golden, Sam A; Pfau, Madeline L et al. (2016) Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice. Neuropharmacology 101:351-7
Moreno, Cesar L; Ehrlich, Michelle E; Mobbs, Charles V (2016) Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT. Neurobiol Dis 85:25-34
Calipari, Erin S; Bagot, Rosemary C; Purushothaman, Immanuel et al. (2016) In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proc Natl Acad Sci U S A 113:2726-31
Wook Koo, Ja; Labonté, Benoit; Engmann, Olivia et al. (2016) Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biol Psychiatry 80:469-78
Friedman, Allyson K; Juarez, Barbara; Ku, Stacy M et al. (2016) KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. Nat Commun 7:11671
Pfau, Madeline L; Russo, Scott J (2015) Peripheral and Central Mechanisms of Stress Resilience. Neurobiol Stress 1:66-79
Christoffel, Daniel J; Golden, Sam A; Walsh, Jessica J et al. (2015) Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress. Nat Neurosci 18:962-4
Chapouly, Candice; Tadesse Argaw, Azeb; Horng, Sam et al. (2015) Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions. Brain 138:1548-67
Bicks, Lucy K; Koike, Hiroyuki; Akbarian, Schahram et al. (2015) Prefrontal Cortex and Social Cognition in Mouse and Man. Front Psychol 6:1805

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