The proposed Neuroscience Training Program will offer prospective predoctoral students an exciting curriculum taught by a nationally and internationally recognized faculty, and a laboratory experience that builds on expertise in translational neuroscience, basic neurobiology, psychiatry and neurology, all uniquely 'interfaced'with one another due to close apposition of clinical and basic neuroscience research at the Mount Sinai Hospital and Mount Sinai School of Medicine. At the heart of the Training Program is Mount Sinai's Neuroscience Ph.D., the school's second Ph.D. granting program (Biomedical Sciences being the first), that was endorsed by the NYU Graduate School and approved by NY State in 2007. Participatingtrainingfaculty share a common thematic interest: study of the function and plasticity of specific neural circuits,during development, in the adult, and in the aged, diseased or degenerating nervous system. Varied laboratory opportunities at Mount Sinai School of Medicine take advantage of particular strengths in translational neuroscience, notably in developmental neurobiology, neural aging and degeneration, mechanisms of neuropsychiatric disease, cognitive neuroscience, computational neuroscience and neuroimaging, sensory signal transduction, neuroendocrinology and synaptic and behavioral plasticity. The nervous system is studied in diverse model systems, from 'simple'invertebrates such as the sea snail Aplysia, the fruit fly, or the worm C. elegans, all the way to complex vertebrates including nonhuman primates and humans. Students will receive a solid foundation in basic neurobiology, in a collaborative environment that actively promotes multidisciplinary, integrative research. Using this interdisciplinary approach, the Neuroscience Training Program will provide four students with the essential knowledge and experimental tools to initiate productive, independent careers in the laboratories of our training faculty.

Public Health Relevance

An estimated four million Americans suffer from Alzheimer's disease, other neurodegenerative conditions including Parkinson's disease, and neuropsychiatricdisease, which cumulatively represent an incredible public health burden. The proposed Neuroscience Training Program will educate talented young scientists, providing a firm foundation for productive, independent careers in neuroscience research and teaching.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHD1-MRG-C (32))
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Desmond, Nancy L
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Icahn School of Medicine at Mount Sinai
Schools of Medicine
New York
United States
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Hodes, Georgia E; Pfau, Madeline L; Leboeuf, Marylene et al. (2014) Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci U S A 111:16136-41
Friedman, Allyson K; Walsh, Jessica J; Juarez, Barbara et al. (2014) Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science 344:313-9
Sepulveda, Bryan; Mesias, Roxana; Li, Xianting et al. (2013) Short- and long-term effects of LRRK2 on axon and dendrite growth. PLoS One 8:e61986
Chen, Dillon Y; Stern, Sarah A; Garcia-Osta, Ana et al. (2011) A critical role for IGF-II in memory consolidation and enhancement. Nature 469:491-7
Sepulveda, B; Carcea, I; Zhao, B et al. (2011) L1 cell adhesion molecule promotes resistance to alcohol-induced silencing of growth cone responses to guidance cues. Neuroscience 180:30-40
Suzuki, Akinobu; Stern, Sarah A; Bozdagi, Ozlem et al. (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144:810-23