The purpose of the proposed training program, """"""""Postdoctoral Training in Reproductive Mood Disorders"""""""" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling;methods for manipulating the reproductive system;and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.

Public Health Relevance

Among women, reproductive mood disorders (postpartum depression, premenstrual dysphoric disorder, and perimenopausal depression) are prevalent and associated with substantial morbidity and mortality. Reproductive mood disorders are similar to other depressive disorders in symptom expression, but they differ in their greater predictability of affective state change resulting from changing reproductive hormone levels. Training the next generation of researchers in reproductive mood disorders will not only increase our understanding of the causes of these debilitating disorders and aid in the identification of therapeutic targets, but because reproductive mood disorders may serve as a model for studying affective state change, our comprehension of the causes of mood disorders overall will also be advanced.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Institutional National Research Service Award (T32)
Project #
1T32MH093315-01A1
Application #
8278091
Study Section
Special Emphasis Panel (ZMH1-ERB-I (01))
Program Officer
Chavez, Mark
Project Start
2012-07-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$134,244
Indirect Cost
$9,581
Name
University of North Carolina Chapel Hill
Department
Psychiatry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Walsh, Erin; Eisenlohr-Moul, Tory; Baer, Ruth (2016) Brief mindfulness training reduces salivary IL-6 and TNF-α in young women with depressive symptomatology. J Consult Clin Psychol 84:887-97
Schweizer, T Sophie; Schmalenberger, Katja M; Eisenlohr-Moul, Tory A et al. (2016) Cognitive and Affective Aspects of Creative Option Generation in Everyday Life Situations. Front Psychol 7:1132
Crowley, Shannon K; O'Buckley, Todd K; Schiller, Crystal E et al. (2016) Blunted neuroactive steroid and HPA axis responses to stress are associated with reduced sleep quality and negative affect in pregnancy: a pilot study. Psychopharmacology (Berl) 233:1299-310
Gordon, Jennifer L; Rubinow, David R; Eisenlohr-Moul, Tory A et al. (2016) Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition. Menopause 23:257-66
Eisenlohr-Moul, Tory; Peters, Jessica R; Chamberlain, Kaitlyn D et al. (2016) Weekly fluctuations in nonjudging predict borderline personality disorder feature expression in women. J Psychopathol Behav Assess 38:149-157
Peters, Jessica R; Eisenlohr-Moul, Tory A; Smart, Laura M (2016) Dispositional mindfulness and rejection sensitivity: The critical role of nonjudgment. Pers Individ Dif 93:125-129
Wouk, Kathryn; Lara-Cinisomo, Sandraluz; Stuebe, Alison M et al. (2016) Clinical Interventions to Promote Breastfeeding by Latinas: A Meta-analysis. Pediatrics 137:
Eisenlohr-Moul, Tory A; Rubinow, David R; Schiller, Crystal E et al. (2016) Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder. Psychoneuroendocrinology 67:142-52
Boggero, Ian A; Eisenlohr-Moul, Tory; Segerstrom, Suzanne C (2016) Task-switching ability protects against the adverse effects of pain on health: A longitudinal study of older adults. Br J Health Psychol 21:434-50
Cone, Jackson J; Fortin, Samantha M; McHenry, Jenna A et al. (2016) Physiological state gates acquisition and expression of mesolimbic reward prediction signals. Proc Natl Acad Sci U S A 113:1943-8

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