This is an extensively revised application for funds to support a longstanding neuropathology training program based on molecular research in disease-based neuroscience. This program emanates from an institution renowned for the integration of cellular and molecular technologies to the study of neurologic disease. This tradition will be continued by a vibrant, multidisciplinary training faculty committed to offer a comprehensive and integrated """"""""Neuroscience Experience"""""""" and to further enforce a scientific environment that is highly conducive for research training. The program is run by an 18 member, highly interactive training faculty with independent research funding and a long history of collaboration. The main goal of the program is to support the training of predoctoral (2 requested) and postdoctoral fellows (4 requested) with state-of the-art molecular approaches to disease-based neuroscience. The Program embraces colleagues in the Depts. of Pathology, Neuroscience, Developmental Molecular Biology, Cell Biology, Microbiology and Immunology and Genetics, and has been instrumental in allowing the involved faculty to maintain prominence in a number of disease entities. We retain a strong presence in Alzheimer's disease and Multiple Sclerosis research, Neuro- AIDS research and Lysosomal Storage Diseases. Parkinson's and Huntington's Diseases were recently included in the list of degenerative disorders researched by newly recruited faculty. Trainees will use cutting-edge molecular, proteomic, structural, genetic and clinical approaches to investigate questions of fundamental importance to neurological diseases including neuroinflammation, neurodegeneration, neuronal and glial cell lineages, development and functions. During the past funding period, we have been very successful in fulfilling an important mandate of a training program, which is to guide trainees to develop into independent scientists. Altogether, the majority of our trainees (around 90%) are still active in neuroscience research and 48% of our former post-doctoral trainees (2000-2010), now hold a faculty appointment. This renewal NRSA, with its 30+ year history, continues to be the major source for pre- and postdoctoral trainees in research in the mechanisms of neurologic disease at this institution and continues to attract first-rate, productive scientists who remain in science after training.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Albert Einstein College of Medicine
Schools of Medicine
United States
Zip Code
Saied-Santiago, Kristian; Townley, Robert A; Attonito, John D et al. (2017) Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Genetics 206:1951-1967
Yang, Mengyu; Arai, Atsushi; Udagawa, Nobuyuki et al. (2017) Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. Sci Rep 7:4928
Zahalka, Ali H; Arnal-Estapé, Anna; Maryanovich, Maria et al. (2017) Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science 358:321-326
Ray, Alex K; DuBois, Juwen C; Gruber, Ross C et al. (2017) Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure. Glia 65:2051-2069
Salzberg, Yehuda; Coleman, Andrew J; Celestrin, Kevin et al. (2017) Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1. PLoS Genet 13:e1006579
Biundo, Fabrizio; Ishiwari, Keita; Del Prete, Dolores et al. (2015) Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory. Neurobiol Learn Mem 126:18-30
O'Guin, Kathleen N; Gruber, Ross C; Raine, Cedric S et al. (2014) Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures. ASN Neuro 6:e00135
Schneider, Jaime L; Cuervo, Ana Maria (2014) Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol 11:187-200
Tarassishin, Leonid; Suh, Hyeon-Sook; Lee, Sunhee C (2014) LPS and IL-1 differentially activate mouse and human astrocytes: role of CD14. Glia 62:999-1013
Gruber, Ross C; Ray, Alex K; Johndrow, Christopher T et al. (2014) Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. J Neurosci 34:16320-35

Showing the most recent 10 out of 148 publications