Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007136-07
Application #
3543670
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1979-08-01
Project End
1989-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
Cho, Yoonsang; Vermeire, Jon J; Merkel, Jane S et al. (2011) Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chem Biol 18:1089-101
Cho, Yoonsang; Crichlow, Gregg V; Vermeire, Jon J et al. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A 107:11313-8
Chiswell, Brian P; Stiegler, Amy L; Razinia, Ziba et al. (2010) Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J Struct Biol 170:157-63
Hoopes, James T; Liu, Xuying; Xu, Xiaomeng et al. (2010) Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem 285:2165-73
Chiswell, Brian P; Zhang, Rong; Murphy, James W et al. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A 105:20677-82
Zito, Christina I; Qin, Hui; Blenis, John et al. (2007) SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem 282:6946-53
Murphy, James W; Cho, Yoonsang; Sachpatzidis, Aristidis et al. (2007) Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem 282:10018-27
Kontaridis, Maria I; Eminaga, Seda; Fornaro, Mara et al. (2004) SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol 24:5340-52
Ivins Zito, Christina; Kontaridis, Maria I; Fornaro, Mara et al. (2004) SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol 199:227-36
Kontaridis, Maria I; Liu, Xiangdong; Zhang, Lei et al. (2002) Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol 22:3875-91

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