This T32 renewal application represents a highly productive, unique, and interdisciplinary Training Program in Neurovirology at the University of Pennsylvania (Penn). Since 1979, we have successfully trained more than forty-five postdoctoral researchers and graduate students for careers in neurovirology and related fields. The program includes ten experienced investigators from three schools at Penn and two additional investigators from other local institutions (Fox Chase, Jefferson). New trainers, Samantha Soldan and Matthew Weitzman (both at Penn) and Matthias Schnell (Jefferson) have been added to further enhance this dynamic program. Our training program has been successful in meeting its mission to identify, mentor and develop future leaders dedicated to biomedical research in the field of neurobiology. We have exceeded our goals to provide opportunities for the following: (1) pre- and postdoctoral research presentations with peer- and mentor-provided critiquing; (2) collaborative project development; (3) enhanced neurobiology research and scholarly interactions within and among institutions in the region (Penn, Fox Chase, Temple, Jefferson, Drexel, Johns Hopkins, and Princeton). During the last funding period, this T32 supported seventeen trainees (seven predoctoral students and ten postdoctoral researchers (including one diversity trainee) under eleven different mentors. Each trainee completed his/her PhD degree or post-doctoral fellowship with at least one peer- reviewed publication, formal oral research presentations in our regular monthly Neurobiology seminar series, and annual participation in at least one national scientific meeting. Past trainees are now established investigators (D. Kolton/Penn Professor;S. Soldan/Penn Asst. Prof.;L. Rong /Univ. of Illinois, Chicago, Professor). Enhanced neurobiology research and scholarly interactions are evidenced by our new neurobiology graduate course (Pathophysiology of Neuroinflammation and Infection in the CNS, 2008), the first Philadelphia-wide Neurobiology Symposium (2012), a new Philadelphia-wide neuroAIDS symposium series (co-established with Temple and Drexel, 2013), and our participation in the Johns Hopkins Encephalitis Symposium (2011). Continued institutional support is provided by the Penn School of Medicine for predoctoral trainees (21 funded months), and postdoctoral trainees (Biomedical Postdoctoral Programs, Susan Weiss, Director). Additional recent enhancements include an Individualized Development Plan for each trainee, a responsible conduct of research component to our monthly meetings, a career panel of alumni of the program and Penn Neurobiology LinkedIn and Facebook groups to track and network with past trainees. The Penn Neurobiology T32 program is distinguished by its: (1) depth and number of research and training opportunities across Schools of Medicine, Veterinary Medicine and Dental Medicine and additional regional institutions; (2) breadth of pathogenic human and animal viruses studied; and (3) unmatched mentoring expertise in basic and translational neurobiology research.

Public Health Relevance

We propose to renew a long-standing Training Program in Neurobiology at the University of Pennsylvania. This Program will support the research training of two predoctoral and two postdoctoral investigators per year in one of eleven laboratories directed by twelve well-established and outstanding Principal Investigators. The goal is to provide focused training in neurobiology and virology to a talented group of future scientists with the goal of understanding the pathogenesis of viruses that infect the nervous system and, in the long term, designing therapies to address the public health problem caused by these infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS007180-32
Application #
8666958
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
1980-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
32
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kovacsics, Colleen E; Gill, Alexander J; Ambegaokar, Surendra S et al. (2017) Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-?-dependent mechanism contributing to HIV neuropathogenesis. Glia 65:1264-1277
Monnerie, Hubert; Romer, Micah; Jensen, Brigid K et al. (2017) Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem 140:53-67
Zalinger, Zachary B; Elliott, Ruth; Weiss, Susan R (2017) Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus. J Neurovirol 23:845-854
Fontana, Juan; Atanasiu, Doina; Saw, Wan Ting et al. (2017) The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane. MBio 8:
Pancholi, Neha J; Price, Alexander M; Weitzman, Matthew D (2017) Take your PIKK: tumour viruses and DNA damage response pathways. Philos Trans R Soc Lond B Biol Sci 372:
Miller, Katelyn D; Rall, Glenn F (2017) What Kaplan-Meier survival curves don't tell us about CNS disease. J Neuroimmunol 308:25-29
Gannon, Patrick J; Akay-Espinoza, Cagla; Yee, Alan C et al. (2017) HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ?-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol 187:91-109
Reyes, Emigdio D; Kulej, Katarzyna; Pancholi, Neha J et al. (2017) Identifying Host Factors Associated with DNA Replicated During Virus Infection. Mol Cell Proteomics 16:2079-2097
Avgousti, Daphne C; Della Fera, Ashley N; Otter, Clayton J et al. (2017) Adenovirus core protein VII down-regulates the DNA damage response on the host genome. J Virol :
Lou, Dianne I; Kim, Eui Tae; Meyerson, Nicholas R et al. (2016) An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates. Cell Host Microbe 20:178-88

Showing the most recent 10 out of 40 publications