This training program in basic and clinical neuroscience has been funded for the past 24 years, and involves the Departments of Neurology, Pediatrics, Neurosurgery, Internal Medicine and Anesthesia at the University of Michigan (U-M) and the Ann Arbor VA Medical Centers. 35,000 square feet of laboratory space are available for basic research, and 30 faculty members, most of whom are both clinical neurologists and basic or clinician scientists, serve as preceptors. We train medical and graduate students, physicians, and basic scientists to conduct basic and clinical neuroscience research. We offer basic science training in cell and molecular neuroscience, neurochemistry, neurophysiology, neuropharmacology, neurogenetics, and clinical science training in the dementias, neuromuscular diseases, movement disorders, sleep disorders and neurogenetics. Clinical training involves evaluation of clinical disorders, clinical-pathological correlations, neuropharmacological interventions, anatomical and functional imaging, including positron emission tomography studies, epidemiological studies, and experimental therapeutics. Training is in the individual laboratory or clinical program but is supplemented by interdisciplinary and collaborative project meetings, seminars and appropriate course work. All trainees in clinical science programs are required to enroll in the School of Public Health's Masters Program in Clinical Research Design and Statistical Analysis. We propose to increase our trainee number from 4 to 5 postdoctoral fellows per year. Postdoctoral trainees are neurologists or physicians in related fields who have completed clinical training and select a basic or clinical research career, and biomedical scientists who seek training in basic neuroscience research. Trainees are selected competitively by the program's Executive Committee. While the Executive Committee monitors progress of trainees, individual preceptors are responsible for guiding their trainees in generating research proposals, supervising the trainees'work, and evaluating the trainees'performance. Efforts are made to recruit qualified women and minority students for training at all levels.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NST-2 Subcommittee (NST)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Koschmann, Carl; Nunez, Felipe J; Mendez, Flor et al. (2017) Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer. Cancer Res 77:227-233
Kamran, Neha; Kadiyala, Padma; Saxena, Meghna et al. (2017) Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy. Mol Ther 25:232-248
Levi Dunietz, Galit; Holzman, Claudia; Zhang, Yujia et al. (2017) Assisted Reproductive Technology and Newborn Size in Singletons Resulting from Fresh and Cryopreserved Embryos Transfer. PLoS One 12:e0169869
Guo, Dewei; Wilkinson, D Andrew; Thompson, B Gregory et al. (2017) MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage. Transl Stroke Res 8:234-243
Dunietz, Galit Levi; Lisabeth, Lynda D; Shedden, Kerby et al. (2017) Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy. J Clin Sleep Med 13:863-870
McGinley, Lisa M; Kashlan, Osama N; Chen, Kevin S et al. (2017) Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice. Ann Clin Transl Neurol 4:749-755
Xiang, Jianming; Routhe, Lisa J; Wilkinson, D Andrew et al. (2017) The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury. Fluids Barriers CNS 14:8
Dunietz, Galit Levi; Matos-Moreno, Amilcar; Singer, Dianne C et al. (2017) Later School Start Times: What Informs Parent Support or Opposition? J Clin Sleep Med 13:889-897
Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725
Green, Katelyn M; Glineburg, M Rebecca; Kearse, Michael G et al. (2017) RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nat Commun 8:2005

Showing the most recent 10 out of 147 publications