This training program in disease-oriented neuroscience has been funded for the past 29 years, and involves the Departments of Neurology, Neurosurgery, Pediatrics, Internal Medicine, Anesthesia, Emergency Medicine, Psychology, Human Genetics, Radiology, Cell &Developmental Biology, Cardiovascular Medicine, Pathology, and Epidemiology at the University of Michigan and the VA Ann Arbor Health System. More than 35,000 square feet of laboratory space are available for basic research, and 42 faculty members, most of whom are physician-scientists, serve as mentors. We train physicians and basic scientists to conduct basic and clinical disease-oriented neuroscience. We offer basic science and translational science training in cell and molecular neuroscience, neurochemistry, neurophysiology, neuropharmacology, and neurogenetics. We offer clinical science training in neurodegenerative disorders, neuromuscular diseases, sleep disorders, stroke, and systems neuroscience. Laboratory based research training is a largely a traditional project oriented approach with careful mentoring by trainee preceptors. Clinical research training involves evaluation of clinical disorders, clinical-pathological correlations, experimental therapeutics, anatomic, molecular and functional imaging, and epidemiological studies. Training is in the individual laboratory or clinical program but is supplemented by interdisciplinary and collaborative project meetings, seminars, and appropriate course work. All trainees in clinical science programs are required to enroll in the School of Public Health's Masters Program in Clinical Research Design and Statistical Analysis. Trainees are neurologists, neurosurgeons, pediatricians, or other physicians who have completed clinical training and select a basic or clinical research career, and biomedical scientists who seek training in disease-oriented basic neuroscience. Trainees are selected competitively by the program's Executive Committee. This training program is embedded within the rich research environment of the University of Michigan which includes a highly collegial and interdisciplinary neuroscience research community, excellent core resources for biomedical research, and strong resources for clinical research. The latter include a very strong School of Public Health, and very strong clinical research and mentoring resources supported by our CTSA. Individual mentors are responsible for guiding their trainees in generating research proposals, supervising trainees'work, and evaluating trainees'performance with additional mentoring provided by discipline specific committees for each trainee and general oversight by the Executive Committee. Our prior trainees have been successful in proceeding to productive academic careers and we have to turn away excellent applicants for training grant positions. We propose to increase our trainee number from 4 to 6 postdoctoral fellows per year. Efforts are made to recruit qualified women and minority students for training at all levels.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007222-33
Application #
8675013
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
1982-07-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
33
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Koschmann, Carl; Nunez, Felipe J; Mendez, Flor et al. (2017) Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer. Cancer Res 77:227-233
Kamran, Neha; Kadiyala, Padma; Saxena, Meghna et al. (2017) Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy. Mol Ther 25:232-248
Levi Dunietz, Galit; Holzman, Claudia; Zhang, Yujia et al. (2017) Assisted Reproductive Technology and Newborn Size in Singletons Resulting from Fresh and Cryopreserved Embryos Transfer. PLoS One 12:e0169869
Guo, Dewei; Wilkinson, D Andrew; Thompson, B Gregory et al. (2017) MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage. Transl Stroke Res 8:234-243
Dunietz, Galit Levi; Lisabeth, Lynda D; Shedden, Kerby et al. (2017) Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy. J Clin Sleep Med 13:863-870
McGinley, Lisa M; Kashlan, Osama N; Chen, Kevin S et al. (2017) Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice. Ann Clin Transl Neurol 4:749-755
Xiang, Jianming; Routhe, Lisa J; Wilkinson, D Andrew et al. (2017) The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury. Fluids Barriers CNS 14:8
Dunietz, Galit Levi; Matos-Moreno, Amilcar; Singer, Dianne C et al. (2017) Later School Start Times: What Informs Parent Support or Opposition? J Clin Sleep Med 13:889-897
Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725
Green, Katelyn M; Glineburg, M Rebecca; Kearse, Michael G et al. (2017) RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nat Commun 8:2005

Showing the most recent 10 out of 147 publications