The aim of our interdisciplinary Institutional Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD pre-/post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Twenty-seven mentors will participate in this second competitive renewal of this program;20 are based primarily at CHOP, and 7 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes: 1) a clinical practicum requirement for both MDs and PhDs, 2) formal course work through the U of P Graduate Studies Program, 3) training in responsible conduct of research, 4) training in biostatistics and 5) workshops that cover a variety of important survival skills, including scientific writing, public presentations, grant writing workshops, laboratory management, and career advancement skills. During the first 9 years of our program, we accepted 19 Trainees;4 were MDs, 14 were PhDs, and 1 was a MD/PhD. 11 of these trainees were female and 4 of these trainees were under-represented minorities. Of the 14 who have completed training, 8 are in faculty positions, 2 are continuing their training at other academic institutions, 1 is a senior research scientist at a pharmaceutical company, 1 is a scientific administrator, and 1 is in private practice. We request continued support for 4 postdoctoral fellows/year and would like to expand our program to include support for 2 pre-doctoral fellows/year. Our goal remains focused on providing a training program unlike any other here at the CHOP or the U of P that is focused on acquired and genetic causes of developmental disability. This program benefits from being in an outstanding environment that commits substantial resources to training, to basic biomedical research, and to a true 'bench to bedside'approach to translational research. Project Relevance: It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. This program strives to fill this need.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZNS1-SRB-P (38))
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Korn, Stephen J
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Children's Hospital of Philadelphia
United States
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Schoch, Hannah; Kreibich, Arati S; Ferri, Sarah L et al. (2017) Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene. Biol Psychiatry 81:193-202
Grafe, Laura A; Cornfeld, Amanda; Luz, Sandra et al. (2017) Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility. Biol Psychiatry 81:683-692
de Marchena, Ashley; Miller, Judith (2017) ""Frank"" presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder. Autism Res 10:653-662
Kwon, Deborah Y; Zhao, Ying-Tao; Lamonica, Janine M et al. (2017) Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC. Nat Commun 8:15315
Grafe, Laura A; Eacret, Darrell; Luz, Sandra et al. (2017) Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress. Neuroscience 348:313-323
Urban, Kimberly R; Valentino, Rita J (2017) Age- and Sex-Dependent Impact of Repeated Social Stress on Intrinsic and Synaptic Excitability of the Rat Prefrontal Cortex. Cereb Cortex 27:244-253
Hu, Peng; Fabyanic, Emily; Kwon, Deborah Y et al. (2017) Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq. Mol Cell 68:1006-1015.e7
Ferri, Sarah L; Kreibich, Arati S; Torre, Matthew et al. (2016) Activation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior. Neuroscience 335:184-94
Parma, Valentina; de Marchena, Ashley B (2016) Motor signatures in autism spectrum disorder: the importance of variability. J Neurophysiol 115:1081-4
De Marchena, Ashley; Eigsti, Inge-Marie (2016) The art of common ground: emergence of a complex pragmatic language skill in adolescents with autism spectrum disorders. J Child Lang 43:43-80

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