Continuing support is requested for a broadly-based, interdisciplinary training program that provides fundamental Pre-doctoral training in the neurosciences at the University of Cincinnati. The proposed training program will support students for the first two years of their graduate education. Trainees are recruited nationally and are selected on a competitive basis. The specific objectives of the training program include: 1) recruiting quality trainees showing outstanding potential for careers in neuroscience;2) delivering solid didactic training in basic neuroscience and the ethical conduct of research, 3) fostering state-of-the art neuroscience research experiences in top neuroscience laboratories, 4) creating an enriched neuroscience environment through journal clubs, seminars, attendance at local, national and international meetings, and numerous events and activities promoting program interaction and cohesion, and 5) preparing students for neuroscience careers through coursework in academic survival skills, career symposia and mentoring. The proposed training program is supported by a growing and vigorous neuroscience community. The University fosters the growth of neuroscience research through faculty recruitments and resource allocation, and supports the Neuroscience Graduate Program through an administrative budget and a limited amount of stipend and tuition support. Participating faculty have active and productive research programs incorporating a variety of approaches to study of the nervous system, spanning basic to translational neuroscience. As a result of this training grant, improvements in our applicant pool have resulted in a very productive and successful student body, as illustrated by the success of our trainees in obtaining quality post-doctoral positions, independent funding and faculty positions. New initiatives proposed for this funding period supplement our program by addition of new courses in neuroscience;implementation of new plans for general and minority recruitment;interaction with the new undergraduate neuroscience major;and public outreach. It is anticipated that our trainees will take an active role In shaping future discoveries of direct benefit to diagnosis, prevention and treatment of nervous system disease or pathology.

Public Health Relevance

;Neuroscience research is critical for discovering new cures and treatments for debilitating neurodegenerative, neurological and psychiatric disease. This proposal provides broad-based training to provide a next generation of scientist's education in the fundamentals of neuroscience and experience in state-of-the-art basic as well as translational neuroscience research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007453-14
Application #
8471201
Study Section
Special Emphasis Panel (ZNS1-SRB-P (54))
Program Officer
Korn, Stephen J
Project Start
1997-09-30
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
14
Fiscal Year
2013
Total Cost
$170,684
Indirect Cost
$8,634
Name
University of Cincinnati
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Nguyen, Elizabeth T; Streicher, Joshua; Berman, Sarah et al. (2017) A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats. Physiol Behav 178:82-92
Jensen, Victoria N; Romer, Shannon H; Turner, Sarah M et al. (2017) Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease. J Vis Exp :
Smith, Brittany L; Lyons, Carey E; Correa, Fernanda Guilhaume et al. (2017) Behavioral and physiological consequences of enrichment loss in rats. Psychoneuroendocrinology 77:37-46
Cassella, Sarah N; Hemmerle, Ann M; Lundgren, Kerstin H et al. (2016) Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring. Schizophr Res 171:195-9
Herman, James P; McKlveen, Jessica M; Ghosal, Sriparna et al. (2016) Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Compr Physiol 6:603-21
Smith, Brittany L; Schmeltzer, Sarah N; Packard, Benjamin A et al. (2016) Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. Brain Behav Immun 57:263-270
Evanson, Nathan K; Herman, James P (2015) Role of Paraventricular Nucleus Glutamate Signaling in Regulation of HPA Axis Stress Responses. Interdiscip Inf Sci 21:253-260
Sullivan, Courtney R; Funk, Adam J; Shan, Dan et al. (2015) Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. PLoS One 10:e0123158
Egan, Ann E; Ulrich-Lai, Yvonne M (2015) Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake. Physiol Behav 150:43-52
Evanson, Nathan K; Herman, James P (2015) Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stress. Physiol Behav 150:2-7

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