The present application is a request for funding for an additional postdoctoral fellow as a supplement to our existing T32 training grant. The purpose of that training grant is to provide outstanding training to postdoctoral fellows in cellular and molecular neurobiology in an environment where basic science and clinical medicine are intertwined, and both are appreciated as important components of the research endeavor. A critical feature of the training is that it is based within the F.M. Kirby Neurobiology Center at Children?s Hospital. As part of both that Hospital and Harvard Medical School, the Center provide a unique high-quality training environment that fosters interactions between outstanding basic scientists and superb clinicians. To ensure that fellows reap the full benefits of this environment, they are assigned a secondary mentor whose orientation complements that of the principle mentor;e.g. a relevant clinician scientist to enhance the training of a fellow in a basic science lab. The research in which our fellows are engaged ranges from very basic research in the functioning of neurons to research that is aimed toward defining the molecular basis of diseases and disorders of the nervous system, including cerebral palsy, autism, epilepsy, Parkinson?s Disease, SMA, brain tumors, and stroke. The present application is for a postdoctoral fellow whose research during the training program will focus on a screen for compounds that enhance neuronal regeneration.

Public Health Relevance

The Supplemental award to our Developmental Neurology Training Program will support a postdoctoral fellow engaged in the study of the regenerative potential of neurons and, as such, is highly relevant to the treatment of brain trauma, spinal cord injury, and peripheral nerve injury

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Sommakia, Salah; Houlihan, Patrick R; Deane, Sadiki S et al. (2017) Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium. J Mol Cell Cardiol 113:22-32
Bae, Byoung-Il; Jayaraman, Divya; Walsh, Christopher A (2015) Genetic changes shaping the human brain. Dev Cell 32:423-34
Kye, Min Jeong; Niederst, Emily D; Wertz, Mary H et al. (2014) SMN regulates axonal local translation via miR-183/mTOR pathway. Hum Mol Genet 23:6318-31
Greene-Colozzi, Emily A; Sadowski, Abbey R; Chadwick, Elyza et al. (2014) Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice. Epilepsy Res Treat 2014:784137
Hedstrom, Kristian L; Murtie, Joshua C; Albers, Kathryn et al. (2014) Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFR?/RET receptor signaling. Proc Natl Acad Sci U S A 111:2325-30
Long, Patrick; Corfas, Gabriel (2014) Dynamic regulation of myelination in health and disease. JAMA Psychiatry 71:1296-7
Badeaux, Aimee I; Shi, Yang (2013) Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol 14:211-24
Badeaux, Aimee I; Shi, Yang (2013) Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol 14:211-24
Yu, Timothy W; Chahrour, Maria H; Coulter, Michael E et al. (2013) Using whole-exome sequencing to identify inherited causes of autism. Neuron 77:259-73
Tsai, Peter T; Greene-Colozzi, Emily; Goto, June et al. (2013) Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet 43:51-9

Showing the most recent 10 out of 30 publications