This proposal seeks to continue the training program in Translational Research in Neurology that has been based in the Department of Neurology at the Emory University School of Medicine. Emory has a large and outstanding faculty who perform cutting edge neurodegenerative disease research. The objective of this program is to provide predoctoral and postdoctoral research training opportunities for individuals interested in pursuing careers in neurtranslational research and to ensure that a diverse and highly trained workforce is available to assume leadership roles related to translational research. Trainees will carry out supervised research with the primary objective of developing their research skills and knowledge in the field of neurological disease with mentors with exceptional scientific and teaching experience from both basic neuroscience and clinical research. Trainees will be prepared to utilize their research findings as they pursue future careers in research. Our program will also provide trainees with training in grant writing so they can obtain future independent research support. Postdocs will also receive training in laboratory and project management. We will provide an outstanding interactive and interdisciplinary environment for learning to design and carry out research investigatiaons that are relevant to neurological disease. The training has 2 main components: First, trainees are immersed in an intensive, hands-on laboratory training program. Second, they learn clinical aspects of neurological disorders, including current concepts of pathogenesis and pathophysiology, current therapy and potential """"""""targets"""""""" for experimental therapeutic intervention. We anticipate recruiting students and PhDs with research experience but little practical knowledge of neurologic disease, and MDs with a firm grasp of clinical neurology but little practical research experience. We will also recruit MD-PhDs who have completed clinical training and now wish to """"""""re-tool"""""""" for a career in neurological research. The faculty who will serve as training mentors are experienced clinician- scientists or basic neuroscientists working on translational research in the Departments of Neurology, Cell Biology, Pharmacology, Human Genetics, Neurosurgery and other clinical and basic science departments.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
Schools of Medicine
United States
Zip Code
Allen, Jessica L; McKay, J Lucas; Sawers, Andrew et al. (2017) Increased neuromuscular consistency in gait and balance after partnered, dance-based rehabilitation in Parkinson's disease. J Neurophysiol 118:363-373
Christopher, Michael A; Kyle, Stephanie M; Katz, David J (2017) Neuroepigenetic mechanisms in disease. Epigenetics Chromatin 10:47
Giddens, Michelle M; Wong, Jennifer C; Schroeder, Jason P et al. (2017) GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis 106:181-190
Sanders, Teresa H (2017) Stimulation of Cortico-Subthalamic Projections Amplifies Resting Motor Circuit Activity and Leads to Increased Locomotion in Dopamine-Depleted Mice. Front Integr Neurosci 11:24
Moody, Olivia A; Talwar, Sahil; Jenkins, Meagan A et al. (2017) Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details. Ann Neurol 81:904-907
Chalermpalanupap, Termpanit; Weinshenker, David; Rorabaugh, Jacki M (2017) Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus. Neural Plast 2017:7829507
MacPherson, Kathryn P; Sompol, Pradoldej; Kannarkat, George T et al. (2017) Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice. Neurobiol Dis 102:81-95
Kalinina, Juliya; Ahn, Jun; Devi, Narra S et al. (2016) Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase. Clin Cancer Res 22:6256-6265
Holler, Christopher J; Taylor, Georgia; McEachin, Zachary T et al. (2016) Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener 11:46
Sanders, Teresa H; Jaeger, Dieter (2016) Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiol Dis 95:225-37

Showing the most recent 10 out of 61 publications