This proposal seeks to continue the training program in Translational Research in Neurology that has been based in the Department of Neurology at the Emory University School of Medicine. Emory has a large and outstanding faculty who perform cutting edge neurodegenerative disease research. The objective of this program is to provide predoctoral and postdoctoral research training opportunities for individuals interested in pursuing careers in neurtranslational research and to ensure that a diverse and highly trained workforce is available to assume leadership roles related to translational research. Trainees will carry out supervised research with the primary objective of developing their research skills and knowledge in the field of neurological disease with mentors with exceptional scientific and teaching experience from both basic neuroscience and clinical research. Trainees will be prepared to utilize their research findings as they pursue future careers in research. Our program will also provide trainees with training in grant writing so they can obtain future independent research support. Postdocs will also receive training in laboratory and project management. We will provide an outstanding interactive and interdisciplinary environment for learning to design and carry out research investigatiaons that are relevant to neurological disease. The training has 2 main components: First, trainees are immersed in an intensive, hands-on laboratory training program. Second, they learn clinical aspects of neurological disorders, including current concepts of pathogenesis and pathophysiology, current therapy and potential "targets" for experimental therapeutic intervention. We anticipate recruiting students and PhDs with research experience but little practical knowledge of neurologic disease, and MDs with a firm grasp of clinical neurology but little practical research experience. We will also recruit MD-PhDs who have completed clinical training and now wish to "re-tool" for a career in neurological research. The faculty who will serve as training mentors are experienced clinician- scientists or basic neuroscientists working on translational research in the Departments of Neurology, Cell Biology, Pharmacology, Human Genetics, Neurosurgery and other clinical and basic science departments.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007480-14
Application #
8669169
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Rose, Samuel J; Kriener, Lisa H; Heinzer, Ann K et al. (2014) The first knockin mouse model of episodic ataxia type 2. Exp Neurol 261:553-62
Deng, Qiudong; Holler, Christopher J; Taylor, Georgia et al. (2014) FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage. J Neurosci 34:7802-13
Ramsey, Chenere P; Tansey, Malu G (2014) A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets. Exp Neurol 256:126-32
Vance, Katie M; Hansen, Kasper B; Traynelis, Stephen F (2013) Modal gating of GluN1/GluN2D NMDA receptors. Neuropharmacology 71:184-90
Pranski, Elaine L; Dalal, Nirjari V; Sanford, Carson Van et al. (2013) RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-*B signaling in dopaminergic cells. Neurobiol Dis 54:264-79
Swanger, Sharon A; He, Yuncen A; Richter, Joel D et al. (2013) Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion. J Neurosci 33:8898-908
Seyfried, Nicholas T; Gozal, Yair M; Donovan, Laura E et al. (2012) Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. J Proteome Res 11:2721-38
Barnum, Christopher J; Pace, Thaddeus W W; Hu, Fang et al. (2012) Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge. J Neuroinflammation 9:9
Donovan, Laura E; Higginbotham, Lenora; Dammer, Eric B et al. (2012) Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease. Proteomics Clin Appl 6:201-11
Herskowitz, Jeremy H; Seyfried, Nicholas T; Gearing, Marla et al. (2011) Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. J Biol Chem 286:6117-27

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