The ability to initiate, execute, and terminate movement effectively is critical for survival but is impaired in a range of debilitating diseases. Precisely how the nervous system encodes movement and how this neural machinery is compromised by disease remain poorly understood. A primary mission of the neuroscience community is to fill these gaps in our knowledge and translate this new information into better clinical practice. To carry this multi-generational effort forward, it is critical that early career scientists are well- trained. They need a firm grasp of what we know and don't know, experimental skills at the molecular, cellular, and systems levels, and dedication to rigorous, quantitative, and ethical research. With these goals in mind, a group of 30 world-leading basic, clinical and translational motor control scientists have come together under the directorship of Dr. D. James Surmeier to deliver a training program for pre- and post- doctoral scientists committed to motor control research at Northwestern University (NU). The goals of the NU General Motor Control Mechanisms and Disease Training Program (GMCMD-TP) are: 1) to educate trainees in basic, translational, and clinical motor systems neuroscience at the molecular, cellular, and systems levels; 2) to provide trainees with the conceptual, technical, and quantitative skillsets necessary to address major questions, challenge dogma and make impactful research discoveries; 3) to encourage trainees to consider the disease relevance of their research and its translational potential; 4) to instill in trainees a deep commitment to rigorous, ethical, and responsible research; 5) to enhance trainees' skills in communicating their research; 6) to give trainees opportunities to advance their career goals so that we support the next generation of leaders in the field of motor control. Pre-doctoral trainees in the NU Interdepartmental Neuroscience (NUIN) program and the Neural Engineering track of the Biomedical Engineering program, and post-doctoral trainees in the laboratories of program faculty are eligible for the GMCMD-TP. The GMCMD-TP consists of: 1) a core course covering each aspect of the motor system, entitled ?The Neural Control of Movement?; 2) monthly seminars by preceptors on their motor control research programs; 3) training and consultation in statistics; 4) an annual retreat where all members of the NU motor control research community come together to communicate and discuss their research; 5) a movement disorders journal club for basic scientists and clinicians; 6) opportunities for shadowing movement disorder clinicians; 7) several annual research center days, each focused on a specific motor control disease. In addition, GMCMD-TP trainees utilize Individual Development Plans and NU professional development programs to further promote career advancement. Each year up to 4 pre-doctoral and 3 post- doctoral trainees will be eligible for direct support for 1-2 years. Trainees in GMCMD-TP labs who do not receive direct support are offered the same training.

Public Health Relevance

Precisely how the nervous system controls movement and how diseases with motor symptoms disrupt this neural machinery remain poorly understood. The aim of the Northwestern University General Motor Control Mechanisms and Disease Training Program is to impart to pre- and post-doctoral scientists the skills necessary to move the motor control field forward and, in doing so, advance the careers of its trainees. Through this program, trainees will learn to appreciate the entire motor system, apply modern experimental approaches, pursue major scientific questions in a rigorous, quantitative and ethical manner, and communicate their research discoveries to both fellow scientists and non-scientists alike.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
2T32NS041234-16A1
Application #
9502654
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Weigand, Letitia Alexis
Project Start
2001-07-15
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
16
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wong, Yvette C; Ysselstein, Daniel; Krainc, Dimitri (2018) Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554:382-386
Cherry, Jonathan J; DiDonato, Christine J; Androphy, Elliot J et al. (2017) In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PLoS One 12:e0185079
Chu, Hong-Yuan; McIver, Eileen L; Kovaleski, Ryan F et al. (2017) Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5
Burbulla, Lena F; Song, Pingping; Mazzulli, Joseph R et al. (2017) Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science 357:1255-1261
Valdez, Clarissa; Wong, Yvette C; Schwake, Michael et al. (2017) Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Hum Mol Genet 26:4861-4872
Glajch, Kelly E; Kelver, Daniel A; Hegeman, Daniel J et al. (2016) Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci 36:5472-88
Wong, Yvette C; Krainc, Dimitri (2016) Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease. Mov Disord 31:1610-1618
Cooper, Garry; Lasser-Katz, Efrat; Simchovitz, Alon et al. (2015) Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 114:1513-20
Suter, Benjamin A; Shepherd, Gordon M G (2015) Reciprocal interareal connections to corticospinal neurons in mouse M1 and S2. J Neurosci 35:2959-74
Rafalovich, Igor V; Melendez, Alexandria E; Plotkin, Joshua L et al. (2015) Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Cell Rep 13:1336-1342

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