We are very pleased to report on the success of our Brain Injury Training Grant (BUG) since its initial funding less than four years ago. Though relatively new, this program has already catapulted trainees into tenure-track professorships and other professional positions where they are pursuing careers as clinician and basic scientists studying injury to the nervous system. In addition, with this resource, we have been able to competitively recruit promising trainees to our program. Furthermore, the intellectual infrastructure formed around this grant has enabled trainees to successfully secure individual NRSA (F31/32) awards and other forms of grant support. In all, there has been a broad impact of the BITG on many young scientists who are now pursuing careers in brain injury research. The continuing principal aim of the BITG is to provide an excellent mentoring environment for M.D. and Ph.D. trainees to prepare them for careers in nervous system injury research. Our trainees acquire basic science research skills that address the etiology, pathogenesis, diagnosis, treatment, and prevention of injury to the nervous system, such as traumatic brain injury (TBI) and cerebral ischemia (stroke). With a large established and cohesive group of investigators participating as mentors, we anticipate that our success will continue. A very unique feature of the BITG is the diversity of disciplines amongst the mentors'laboratories, all focused on nervous system injury research. Due in part to the remarkable proximity of schools and departments at the University of Pennsylvania, there has been a long history of multidisciplinary collaborations spanning cell biology, molecular biology, neuropathology, neuroengineering, neurology, neuroanatomy, cognitive science, neuroimaging and neuropharmacology. This integrated resource will continue to enable trainees to learn and develop a multidisciplinary approach to training in investigation of injury to the nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS043126-10
Application #
8261721
Study Section
Special Emphasis Panel (ZNS1-SRB-S (16))
Program Officer
Korn, Stephen J
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$147,746
Indirect Cost
$18,607
Name
University of Pennsylvania
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Jackson, Dan P; Ting, Jenhao H; Pozniak, Paul D et al. (2018) Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS. Mol Cell Neurosci 92:1-11
Wolf, John A; Johnson, Brian N; Johnson, Victoria E et al. (2017) Concussion Induces Hippocampal Circuitry Disruption in Swine. J Neurotrauma 34:2303-2314
Katiyar, Kritika S; Winter, Carla C; Struzyna, Laura A et al. (2017) Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration. J Tissue Eng Regen Med 11:2737-2751
Wofford, Kathryn L; Harris, James P; Browne, Kevin D et al. (2017) Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine. Exp Neurol 290:85-94
Coats, Brittany; Binenbaum, Gil; Smith, Colin et al. (2017) Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets. J Neurotrauma 34:235-247
Merkow, Maxwell B; Burke, John F; Ramayya, Ashwin G et al. (2017) Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting. Brain Stimul 10:645-650
Struzyna, Laura A; Adewole, Dayo O; Gordián-Vélez, Wisberty J et al. (2017) Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling. J Vis Exp :
Cullen, D Kacy; Harris, James P; Browne, Kevin D et al. (2016) A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration. Methods Mol Biol 1462:289-324
Harris, J P; Struzyna, L A; Murphy, P L et al. (2016) Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain. J Neural Eng 13:016019
Yu, Ki Jun; Kuzum, Duygu; Hwang, Suk-Won et al. (2016) Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. Nat Mater 15:782-791

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