This second competing renewal application of a T32 program initiated in 2002 retains as its goal to provide experiential training in molecular and mechanistic research to post- DVM/VMD candidates with residency specialization. Graduates from the program will have unique skills to bridge basic research to in vivo translation with impact on human and animal health in a time of emerging diseases, biosecurity, and One Medicine. The training program builds on a robust initial phase of residency training funded by non-T32 sources to merge seamlessly to the T32-supported mentored research training emphasizing modern multidisciplinary methods linked to translational application. The program also stresses critical thinking in experimental design and data interpretation, scientific writing, publication, communication skills, and the ethical conduct of research. The desired outcome of this training program is production of DVM/VMD scientists who will become successful NIH-funded principal investigators able to respond to national human and animal health priorities. The program is guided by experienced leadership, counseled by an external advisory committee comprised of expert T32 Program Directors, populated with diverse faculty skilled in research mentorship. Major indicators of success in the first 9 years of this award include: (1) successful recruitment and retention of trainees since inception;(2) attainment of the PhD by all 10 eligible trainees to date--6 of whom have received NIH K career development awards, 8 of whom are appointed in junior faculty level positions focusing on research;and, (3) the generation of ~75 scientific publications by T32 trainees. Here we apply for support to continue this productive training program at its present level.
This research training program requests resources for stipend and tuition to support graduate training for veterinarians in public and human health related fields. As many emerging infectious diseases of humans are spread from and/or are infectious to animals, and as many human cancers and spontaneously occurring diseases also exist in animals, or are studied in animal models, veterinarians trained in research are essential to advancement of public health.
|Ledesma-Feliciano, Carmen; Hagen, Sarah; Troyer, Ryan et al. (2018) Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential. Retrovirology 15:38|
|Takeda, Katsuyuki; Webb, Tracy L; Ning, Fangkun et al. (2018) Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation. J Immunol 200:1261-1269|
|Russo, Joseph; Jalkanen, Aimee L; Heck, Adam M et al. (2018) Sequences encoding C2H2 zinc fingers inhibit polyadenylation and mRNA export in human cells. Sci Rep 8:16995|
|Magnuson, A M; Regan, D P; Fouts, J K et al. (2017) Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations. Cell Prolif 50:|
|Johnson, Valerie; Webb, Tracy; Norman, Annalis et al. (2017) Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections. Sci Rep 7:9575|
|Davenport, Kristen A; Hoover, Clare E; Bian, Jifeng et al. (2017) PrPC expression and prion seeding activity in the alimentary tract and lymphoid tissue of deer. PLoS One 12:e0183927|
|Hoover, Clare E; Davenport, Kristen A; Henderson, Davin M et al. (2017) Endogenous Brain Lipids Inhibit Prion Amyloid Formation In Vitro. J Virol 91:|
|Chow, Lyndah; Johnson, Valerie; Coy, Jonathan et al. (2017) Mechanisms of Immune Suppression Utilized by Canine Adipose and Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Dev 26:374-389|
|Hoover, Clare E; Davenport, Kristen A; Henderson, Davin M et al. (2017) Pathways of Prion Spread during Early Chronic Wasting Disease in Deer. J Virol 91:|
|Podell, Brendan K; Ackart, David F; Richardson, Michael A et al. (2017) A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment. Dis Model Mech 10:151-162|
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