The Research Training Program in Veterinary and Comparative Pathology at Harvard Medical School (HMS) is designed to prepare veterinarians for careers in biomedical research, with an emphasis on training in experimental pathology and in the use of nonhuman primate (NHP) models to study the pathogenesis and treatment of human diseases. This training grant is centered at the New England Primate Research Center (NEPRC) and includes the participation of other components of HMS and other area institutions. All trainees are at the postdoctoral level and are appointed as Research Fellows in the Department of Pathology of HMS. The training program is designed to follow a one year, NEPRC-funded period of intensive training in anatomical pathology. After appointment to the NCRR T32 program, trainees receive instruction in the design and implementation of experiments using NHP models, mentoring in the preparation of NIH grant applications and the peer review process, and broad exposure to state-of-the-art investigative tools and contemporary research methods used in experimental pathology, including immunohistochemistry, immunoelectron microscopy, in situ hybridization, flow cytometry, confocal microscopy, laser capture microdissection, PCR, and molecular biology. The training program will include formal coursework at HMS and the Harvard School of Public Health, participation in research conferences and seminars at the NEPRC, attendance at national and regional pathology and scientific meetings, and the completion of a research project under the supervision of an established investigator that results in the publication of manuscripts in peer-reviewed journals. Trainees pursuing a graduate degree may apply the research projects performed while supported by this training grant towards the fulfillment of the requirements of a PhD in graduate programs at Harvard University or the University of Massachusetts Medical School. Thus, this comprehensive training program will integrate the unique resources of the NEPRC, the outstanding research environment of Harvard Medical School and its affiliated institutions, and a field of established investigators to accomplish the long-term objective of providing qualified veterinarians with the requisite research training and experience to enable them to successfully compete for research funding as they prepare for academic careers as experimental pathologists and research scientists.

Public Health Relevance

(provided by applicant): The Research Training Program in Veterinary and Comparative Pathology at Harvard Medical School is designed to provide advanced training to veterinarians for careers in biomedical research. Such individuals are valuable for their multidisciplinary skills and provide critical functions in addressing a variety of important human and animal health issues.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Institutional National Research Service Award (T32)
Project #
5T32RR007000-35
Application #
8080856
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Watson, William T
Project Start
1978-07-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
35
Fiscal Year
2011
Total Cost
$332,171
Indirect Cost
Name
Harvard University
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Breed, Matthew W; Jordan, Andrea P O; Aye, Pyone P et al. (2013) Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression. J Virol 87:1528-43
Cummings Macri, S; Knight, H L; Miller, A D (2013) Mesenchymoproliferative enteropathy associated with dual simian polyomavirus and rhesus cytomegalovirus infection in a simian immunodeficiency virus-infected rhesus macaque (Macaca mulatta). Vet Pathol 50:715-21
Harbison, Carole E; Ellis, Mary E; Westmoreland, Susan V (2013) Spontaneous cervicovaginal lesions and immune cell infiltrates in nonhuman primates. Toxicol Pathol 41:1016-27
Bailey, C C; Miller, A D (2012) Ulcerative cheilitis in a rhesus macaque. Vet Pathol 49:412-5
Assaf, Basel T; Mansfield, Keith G; Westmoreland, Susan V et al. (2012) Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection. J Virol 86:6354-7
Sasseville, V G; Mansfield, K G; Mankowski, J L et al. (2012) Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol 49:1057-69
Bailey, Charles C; Huang, I-Chueh; Kam, Christina et al. (2012) Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog 8:e1002909
Masek-Hammerman, K; Miller, A D; Lin, K C et al. (2012) Epizootic myocarditis associated with encephalomyocarditis virus in a group of rhesus macaques (Macaca mulatta). Vet Pathol 49:386-92
Macri, Sheila C; Bailey, Charles C; de Oca, Nicole Monts et al. (2012) Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart. Toxicol Pathol 40:637-46
Assaf, B T; Miller, A D (2012) Pleural endometriosis in an aged rhesus macaque (Macaca mulatta): a histopathologic and immunohistochemical study. Vet Pathol 49:636-41

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