It is often stated that the oral health problems facing our nation extend beyond primary disease or developmental pathologies, but are complex and multi-factorial to include genetic, social, cultural, behavioral and environmental factors. In order to effectively manage oral health problems we need to address the multi- factorial nature of these conditions. It is our hypothesis that to comprehensively addressing these oral health needs requires individuals who can not only advance the science and discovery processes, but who can also lead and be effective members of multidisciplinary teams. Addressing the oral needs of the nation will require interdisciplinary teams a uniquely trained group of scientists who not only have a firm understanding of the multi-factorial components of the complex oral, dental and craniofacial diseases, but who can also be effective leaders or members of interdisciplinary teams. Clearly, the era of solo or tower-based science programs has passed and highly effective research involves teams of clinicians and scientists. The purpose of this proposed training program is to develop a cohort of successful, independent, basic, clinical and translational Oral Health Research Scholars who can function as interactive scientists to address the nation's healthcare needs in dental, oral and craniofacial research. As designed, our program embraces the full spectrum of basic, translational and clinical research including fundamental mechanisms of human disease, therapeutic intervention, clinical trials, oral epidemiology, health services research and health policy. Our goal is to create a new cadre of highly interactive scientists who can serve as research leaders in academic dentistry and research institutions. The NextGen program encompasses three Ph.D. degree granting curricula and training in Oral Biology;Health Policy and Management, or Oral Epidemiology;one M.S. degree granting curriculum and training for Dentists in Clinical Research;and a postdoctoral fellowship for individuals seeking advanced research opportunities in Oral Biology, Health Policy/Management, or Oral Epidemiology The objectives of the UNC NextGen Training Program are to: 1. Train a cadre of oral health scientists able to conduct research in a multidisciplinary setting by recruiting high quality trainees into the five components of our proposed program leading to Ph.D. and M.S. degrees or postdoctoral research fellowship. 2. Expand our current recruitment efforts targeting under-represented minorities and women and incorporate career development components designed to retain these researchers in academic settings. 3. Provide trainees with the necessary didactic and experiential training so that each can develop and apply skills in various cutting edge technologies, such as functional genomics, bioinformatics, and systems biology, for the purpose of rigorous biomedical, behavioral, and clinical research. 4. Provide opportunities for formal training in career development skills that include experimental design, biostatistics and data analysis, manuscript and grant writing, clinical trials coordination and management, data base management, responsible conduct of research, and ethics. 5. Provide opportunities for formal and experiential leadership training (conflict resolution, team management, and cultural competency), permitting trainees to function as leaders and effective members of research teams that integrate multidisciplinary activities ranging from molecules to populations. 6. Facilitate transition of T90 trainees to individual research training awards or other mechanisms of research training support and assist them in career development.

Public Health Relevance

The oral health problems facing our nation extend beyond primary disease or developmental pathologies to include genetic, social, cultural, behavioral and environmental factors. The appropriate response is a multidisciplinary research workforce who have been trained to not only advance the science and discovery processes, but who can also lead and participate in multidisciplinary teams to solve complex problems that will ultimately improve the health of the public.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Research Training Award (T90)
Project #
5T90DE021986-02
Application #
8271266
Study Section
Special Emphasis Panel (ZDE1-RW (09))
Program Officer
King, Lynn M
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$639,485
Indirect Cost
$42,353
Name
University of North Carolina Chapel Hill
Department
Dentistry
Type
Schools of Dentistry
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Akinkugbe, A A; Sharma, S; Ohrbach, R et al. (2016) Response to Letter to the Editor, ""Directed Acyclic Graphs for Oral Disease Research"". J Dent Res 95:1315
Morelli, Thiago; Moss, Kevin L; Beck, James et al. (2016) Derivation and Validation of the Periodontal and Tooth Profile Classification System for Patient Stratification. J Periodontol :1-17
Sanders, Anne E; Akinkugbe, Aderonke A; Slade, Gary D et al. (2016) Tooth loss and obstructive sleep apnea signs and symptoms in the US population. Sleep Breath 20:1095-102
Akinkugbe, Aderonke A; Sanders, Anne E; Preisser, John S et al. (2016) Environmental tobacco smoke exposure and periodontitis prevalence among nonsmokers in the hispanic community Health Study/Study of Latinos. Community Dent Oral Epidemiol :
Akinkugbe, A A; Sharma, S; Ohrbach, R et al. (2016) Directed Acyclic Graphs for Oral Disease Research. J Dent Res 95:853-9
Sanders, Anne E; Akinkugbe, Aderonke A; Bair, Eric et al. (2016) Subjective Sleep Quality Deteriorates Before Development of Painful Temporomandibular Disorder. J Pain 17:669-77
Akinkugbe, Aderonke A; Slade, Gary D; Divaris, Kimon et al. (2016) Systematic Review and Meta-analysis of the Association Between Exposure to Environmental Tobacco Smoke and Periodontitis Endpoints Among Nonsmokers. Nicotine Tob Res :
Burger-Calderon, Raquel; Ramsey, Kathy J; Dolittle-Hall, Janet M et al. (2016) Distinct BK polyomavirus non-coding control region (NCCR) variants in oral fluids of HIV- associated Salivary Gland Disease patients. Virology 493:255-66
Galicia, J C; Henson, B R; Parker, J S et al. (2016) Gene expression profile of pulpitis. Genes Immun 17:239-43
Dissinger, Nathan J; Damania, Blossom (2016) Recent advances in understanding Kaposi's sarcoma-associated herpesvirus. F1000Res 5:

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