In response to Program Announcement PAR-10-170 from the NIDCR to provide Institutional Training for a Dental and Craniofacial Workforce, a T90/R90 Comprehensive Training Program in Oral Biology is proposed. The proposal builds on twenty years of experience with a highly productive T32 Training Program in Oral Biology at the University of Florida College of Dentistry (UFCD) and will provide breadth and depth in training to basic and clinician scientists in multiple areas that are designated as high priority by the NIDCR. The scientific areas encompassed in this Comprehensive Training Program in Oral Biology include Oral Infectious Diseases, Oral:Systemic Health Connections, Autoimmunity, Bone Biology, Gene Therapy and Stem Cell Biology, Oral Cancers, Salivary Gland Biology, and Pain. To accomplish our goals, a team of experienced and well-funded basic and clinical researchers has been assembled to provide an extensive set of training experiences in the biomedical sciences that are directly relevant to oral health and diseases. Established and time-tested interdisciplinary research training programs in the UFCD and the UF College of Medicine will be utilized, with particular emphasis on the Interdisciplinary PhD Program in Biomedical Sciences and the CTSA- supported Clinical and Translational Science Institute. Trainees will include i) traditional PhD students conducting oral health-related research, ii) dual-degree candidates in our newly-developed DMD-PhD program, iii) DMD/DDS holders seeking a PhD and clinical specialty, iv) traditional post-doctoral PhD scientists, and v) DMD-DDS holders seeking advanced post-doctoral training to prepare them for careers in academic dentistry. Formal training in Clinical Investigation will be available to all individuals supported by the program. The use of combinations of our extensive educational, scientific and clinical resources has allowed us to develop highly integrated yet sufficiently flexible training options to meet the needs of a heterogeneous group of trainees. Collectively, these programs will produce a group of highly skilled and interactive scientists who will generate new knowledge and translate discoveries to tangible advances in the detection, prevention, treatment and cure of diseases and abnormalities of the oral and craniofacial complex.
In response to a request from the National Institute for Dental and Craniofacial Research to provide Institutional Training for a Dental and Craniofacial Workforce, the University of Florida College of Dentistry has developed a Comprehensive Training Program in Oral Biology. The proposal builds on twenty years of successful training of basic and clinician scientists in oral health research. Using the extensive educational, scientific and clinical resources at our University, we will provide a comprehensive series of pre- and post- doctoral training opportunities in research areas that directly relate to oral health and diseases. Collectively, these programs will produce a group of highly skilled and interactive scientists who will generate new knowledge and translate their discoveries to advances in the detection, prevention, treatment and cure of diseases and abnormalities of the oral and craniofacial complex.
|Huang, Xuelian; Browngardt, Christopher M; Jiang, Min et al. (2018) Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans. Caries Res 52:88-101|
|Liu, Yuan; Palmer, Sara R; Chang, Hsiaochi et al. (2018) Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model. Environ Microbiol Rep 10:12-22|
|Kaspar, Justin; Shields, Robert C; Burne, Robert A (2018) Competence inhibition by the XrpA peptide encoded within the comX gene of Streptococcus mutans. Mol Microbiol 109:345-364|
|Underhill, Simon A M; Shields, Robert C; Kaspar, Justin R et al. (2018) Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence. mSphere 3:|
|Brice, David C; Toth, Zsolt; Diamond, Gill (2018) LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells. Antiviral Res 158:25-33|
|Avilés-Reyes, A; Freires, I A; Kajfasz, J K et al. (2018) Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans. Mol Oral Microbiol 33:257-269|
|Lee, Kyulim; Roberts, JoAnn S; Choi, Chul Hee et al. (2018) Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells. Virulence 9:845-859|
|Avilés-Reyes, Alejandro; Freires, Irlan Almeida; Besingi, Richard et al. (2018) Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins. Sci Rep 8:4705|
|Delitto, Andrea E; Rocha, Fernanda; Decker, Ann M et al. (2018) MyD88-mediated innate sensing by oral epithelial cells controls periodontal inflammation. Arch Oral Biol 87:125-130|
|Park, Yuk Pheel; Jin, Linchun; Bennett, Katie B et al. (2018) CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma. Oral Oncol 78:145-150|
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