Abstract

The proposed program in research training and education is designed to prepare NRSA and non-NRSApostdoctoral trainees for careers in the emerging field of 'geroscience' the integrated, interdisciplinarystudy of aging and age-related diseases. The Buck Institute for Age Research is uniquely positioned toprovide broad-based training and education in this field, and thereby ready its participants to make importantcontributions to our understanding of the biology of aging and its attendant health consequences. Some keyassets of the Buck Institute in this regard are its strong institutional focus on aging research, highlyinterdisciplinary approach to research problems, advanced technologic infrastructure, outstanding facultywith diverse scientific and clinical expertise and prior teaching experience, and the unsurpassed regionalresearch environment and facilities of the San Francisco Bay Area. The Buck Institute has devoted majoreffort and resources to the training of junior scientists, especially postdoctoral fellows, in aging research. Inaddition to working in the laboratories of Buck Institute faculty members, these fellows have access todidactic courses designed to better equip them for independent careers in aging research in academic orbiotechnology settings, as well as practical instruction in career-development skills including research ethics,scientific presentations, grant writing and teaching. This postdoctoral training program's Specific Aims are to:
AIM 1. Provide postdoctoral trainees with interdisciplinary laboratory experience in geroscience theintegrated study of aging and age-related diseases.
AIM 2. Provide postdoctoral trainees with didactic teaching in disciplines inherent to geroscience andpractical instruction that will assist in their scientific career development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Linked Training Award (TL1)
Project #
1TL1AG032116-01
Application #
7466726
Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Sierra, Felipe
Project Start
2007-09-30
Project End
2012-06-30
Budget Start
2007-09-30
Budget End
2008-06-30
Support Year
1
Fiscal Year
2007
Total Cost
$101,166
Indirect Cost

  Institution

Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945

  Publications

Brand, Martin D; Goncalves, Renata L S; Orr, Adam L et al. (2016) Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab 24:582-592
Goncalves, Renata L S; Quinlan, Casey L; Perevoshchikova, Irina V et al. (2015) Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise. J Biol Chem 290:209-27
Orr, Adam L; Vargas, Leonardo; Turk, Carolina N et al. (2015) Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol 11:834-6
Orr, Adam L; Ashok, Deepthi; Sarantos, Melissa R et al. (2014) Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. PLoS One 9:e89938
Quinlan, Casey L; Goncalves, Renata L S; Hey-Mogensen, Martin et al. (2014) The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem 289:8312-25
Goncalves, Renata L S; Rothschild, Daniel E; Quinlan, Casey L et al. (2014) Sources of superoxide/H2O2 during mitochondrial proline oxidation. Redox Biol 2:901-9
Quinlan, Casey L; Perevoschikova, Irina V; Goncalves, Renata L S et al. (2013) The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol 526:189-217
Quinlan, Casey L; Perevoshchikova, Irina V; Hey-Mogensen, Martin et al. (2013) Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol 1:304-12
Orr, Adam L; Ashok, Deepthi; Sarantos, Melissa R et al. (2013) Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radic Biol Med 65:1047-1059
Brand, M D; Orr, A L; Perevoshchikova, I V et al. (2013) The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol 169 Suppl 2:1-8

Showing the most recent 10 out of 17 publications